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Flashcards in TTR Deck (20)
1

Treatment for ET

Propanolol

 

DBS

1

what dp you look for on imaging when doing a seizure workup? 

 

 

between seizures what do you look for of EEG? 

Medial Temporal Sclerosis or Cortical Dysplasia or tumor

 

 

Look for Inter-Ictal Spike --> spark for seizures 

2

considerations in treatment in kids w absent seizures

Cognitive side effects - Topiramate

Bheavioral - Phenobarb, Levetiracetam

 

weight loss in growing child - topiramate

 

Valproid acid - Girls in puberty !!! 

3

What are causes of worsening ischemic stroke? 

Cytotoxic brain edema

Symptomatic Hemorrhagic Transformation

Herniation

Recurrent Ischemic Stroke

4

Childhood Absense DX feature

 

JME Dx Feature

3 spikes/second - absence

 

4-6 / sec JME 

5

What is Apomorphine?

DA Agonist Rescue Therapy for Parkinson's Disease Acts right away and can be given when run out of dosing for LDOPA

6

What do you worry about w/ Dermatomyositis? 

CANCER!! Also a paraneoplastic syndrome 

7

Most common death in people w/ movement disorder? 

Pneunomia!! - from dysphagia 

8

Treatment for Huntingtons? 

Tetrabenazine - DA blocker that suppresses Chorea but not other symptoms 

9

Lambert Eaton is what? Associated w what? 

SMALL CELL CARCINOMA!!!! Paraneoplastic syndrome

 

Pre-synaptic Ca channel!!!

 

Pts are worse in morning and better throughout the day w/ activity 

11

Name the Taupathies. 

 

 

Name the Synucleinopathies

Taupathies: 

  • AD
  • FTD - Picks Disease
  • PSP - Tau + Vertical Gaze PAral
  • CBD - Tau + Alien Limb Phenomenon
  • CTE

 

Alpha-Synuclein

  • PKD
  • LBD
  • MSA - but Alpha synuclein in Oligodendrocytes in 3 places!!! 

12

Symptoms of Tabes Dorsalis? 

No sense of proprioception, Charcot Joints, Rhomberg signe 

 

Syphilis causes loss of myelin and axons in neurons of Dorsal column 

 

Lose DTR

13

what disease makes " moth eaten white matter"?

PML - Oligod inclusions 

 

PLaques are yellow-ish from lipid laden macrophages

14

clues for Guillan Barre

"cytoalbuminogenic" CSF - normal cells but high protein from demyelination 

 

Endoneurial lymphocytes

segmental demyualination 

T cells and Macrophages 

15

6 yo girl w/ developmental delay, weakness and scoliosis goes in for surgery and dies from malignant hyperthermia - what does she have

Central Core Disease - Type 1 Fiber centers where NADH-reductase in mitochondira not reactive and central core looks pale

 

AD inheritance of RYR1 

16

17 yo girl w/ intractable migraine, ex intolerance, muscle pain and cramping

Left Homonymous hemianospia

Elevated CPK and LACTIC ACIDOSIS 

MELAS = Migraine, Episodes that are stroke-like, Lactic Acisosis , Seizures 

 

Ragged Red Fibers

Paracrystalline Parking lot mitochondrial inclusions

 

Encephalomyopathy, Lactici Acidosis, Stroke-like Episodes 

 

Maternal Interhitance

Heteroplasmy - uneven segregation of mitochrondia w/in cells 

17

Treatments for AD

Cholinesterase Inhibitors: Donezapil, Rivastigmine, Galantamine

 

NMDA Antagonists - Memantine 

 

DO NOT GIVE - AntiCholinergics

- Oxybutinin, Benztropine, Diphenhydramine, PAroxetine, Amitryptiline, Trihedyphenidryl

18

what does neuroimaging of PTSD show? 

Increased activity in Amygdala - threat processing

Decreased activity in Medial Prefrontal Cortex - Fear Regulation

19

What is Prazosin? What is it used for? 

Prazosin is a Anti-HTN Medicaiton that is an Alpha Adrenergic blocker but is used in PTSD to reduce nightmares

20

Buprenorphine

 

Buprioprione

 

Buspirone 

 

What are each of these and how do you use theM 

Buprenorphine - Partial Mu Agonist used for opiate addictoin 

 

Buspirone- 5HT1A Partial Agonist used to treat GAD

 

Bupropione - NDRI antidepressant used to quit smoking