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Flashcards in Schizophrenia Deck (67)
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1

Paliperidone (Invega), Risperidone (Risperdal)

Dose, metabilism how to take blah blah blah

2

What atypicals are highest for weight gain? What are the lowest?

Clozapine, Olanzapine

 

Aripiprazole, Lurasidone, Ziprasidone 

3

How can Akathisia be treated?

 

  • Reducing the dose of the AP 
  • You can switch to a low dose AP or SGA
  • Beta blockers like propranolol can help
  • Benzos

4

FGA, and SGAs both have effects on other receptors besides Dopamine and 5-HT2a what are the other receptors?

  • Muscarinic (cholinergic) receptors
  • A1 receptors
  • Histamine

 

5

What are the positive symptoms of schizophrenia?

  • Delusion
  • Hallucination
  • Disorganized speech
  • Unusual behavior
  • Hostility, agitation, combativeness

6

Talk about Asenapine, Iloperidone, Lurasidone?

Dose, metabilism how to take blah blah blah

7

Comparison of Typical APs

8

Drugs can induce psychosis what are the illicit ones?

Cocaine, PCP, Amphetamines, Mary Jane, LSD, Ketamine

 

9

Residual signs and symptoms 

 

  • Anxiety 
  • Suspicousness
  • Lack of motivation
  • poor insight and judgement 

 

10

What is the nonpharmacologic treatment for schizophrenia?

  • Psychsocial rehab programs
  • case management
  • support groups 
  • psychotherapy

11

What are some SEs of histamine and what is its therapeutic effects?

  • Sedation and weight gain 
  • Sedation is its therapeutic effects

 

12

Olanzapine (Zyprexa), Quetiapine (Seroquel), Ziprasidone (Geodon)

Dose, metabilism how to take blah blah blah

13

For SGAs when do you monitor 

Weight

Waist

Glucose

Hyperlipidemia

  • monthly for first 3 months then quarterly 
  • ANual
  • 3 months then anually if normal
  • 3 months then anually if normal 

SKIPPED other ones 

14

What differientates between a good a bad prognosis?

  • Good mainly positive symptoms dominate
  • older than the average person to get diagnosed

 

  • Poor
    • Patient is younger than average when diagnosed
    • (+) FH
    • Negative symptoms are big 

15

Symptoms for Neuroleptic Malignant Syndrome?

FEVER

Fever

Encephalopathy

Vital unstable

Elevated Enzymes (CK)

Rigidity

16

Aripiprazole (Abilify), Brexipiprazole (Rexulti), Cariprazine (Vraylar)

Dose, metabilism how to take blah blah blah

17

Negative symptoms?

  • Blunted/flat affect
  • Avolition (no motivation)
  • Anhedonia (lack of pleasure)
  • Poverty of Speech (Alogia)
  • Psychotomotor retardation

 

18

What atypicals are indicated for Irritability in Autism?

  • Apripirazole
  • Risperidone

19

The onset of schixophrenia in females occurs?

in their late 20s

20

Thiordazine cause?

This makes it a unlikely choice when chosing an antipsychotic

QTC Prlongation it can cause sudden death!

21

What are the social and occupational symptoms of schizophrenia?

  • Isolation 
  • Decrease self-care
  • poor hygiene
  • Dirty unkept
  • Difficulty with family and social relationships 
  • Employment difficulties 

 

22

Comparison of Atypical APs

EPS?

Akathisia?

Wt gain?

Hyperprolactin?

QTC

Ortho

Sedation 

 

23

Excluding aripiprazole, brexipiprazole, cariprazine

What are the other atypical antipsychotic mechanism of action?

5-HT2a/ Dopamine D2 antagonist

 

24

tardive dyskinesia?

  • Facial movements
  • tongue
  • lip
  • neck and trunk
  • limb

 

25

What is the prodromal stage of schizophrenia?

No obvious symptoms are present but daily function begins to decline

  • Pts begin to become withdrawn, suspicious, and have an odd behavior?

26

The mesocortical system is responsible for the ____ symptoms of schizophrenia?

negative

27

The onset of schizophrenia in males usually occurs?

In their early 20s

28

Treatment for NMS?

Discontinue the AP, dopamine agonist, dantrolene IV or PO

29

What side effects are greater in SGAs compared to FGAs?

 

 

  • Weight gain
  • DM
  • Hyperlipidemia

All of these are related

30

The only treatment for TD is?

Prevention so you have to constantly be checking on the person every 3-6 months if they are on a FGA. 

It can be irreversible but if caught early enough you may be able to stop the progression