sem 2: cardiac drugs Flashcards
2 sinoatrial drugs to reduce Hr and contractility
If channel blockers
Ca channel blockers
NS drug that reduce HR and contractility
B1- antagonists - atenolol
3 subtypes of Ca channel blocker
dihydropyridines
diphenylalkamines
benzothiazepines
example of an If channel blocker
Ivrabradine
what does an If channel blocker do
increases phase 4- slower to activate Ca channels, take s longer to reach hyperpolarisation threshold
what is an If channel blocker used in
angina - lower HR
example of a B1 antagonist
atenolol
reduced O2 demand
what is B1 antagonist not used with
Ca channel blocker
example of a M antagonist
atropine
inc HR following MI
side effects of M antagonist
overactive bladder, tachycardia
what is a PDE inhibitor
prevents breakdown of cAMP
activation of PKA
used in severe and chronic cases
what is a Gs coupled receptor agonist going to do
increase HR and contractility
not used in chronic cases as it increases O2 demand
what is another example of a Ca 2+ rising process
cardiac glycosides e.g. digoxin
inhibits Na/K so build up of Na within
less Na/Ca exchange
greater CICR
2 drugs to reduce afterload
ACEi
diuretics
drug to increase coronary artery blood flow and relieve angina
Nitrate donot( GTN spray)
