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SEM 1 + 2 CVS > sem 2: contractility and ionotropic effects > Flashcards

sem 2: contractility and ionotropic effects Flashcards

1
Q

what is the chronotropic effect

A

heart rate

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2
Q

what is the ionotropic effect

A

contractility

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3
Q

what is the lusitropic effect

A

relaxation

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4
Q

what is the dromotropic effect

A

conduction

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5
Q

what happens in cardiac contraction

A 
in phase 2 - calcium is released 
activated RYR on SR 
CICR 
troponin system activated 
myosin binds to actin and crossbridge formation
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6
Q

3 ways of reducing Ca

A

Na/Ca exchanger
SERCA
uptake into mitochondria

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7
Q

how does the sympa system inc contractility

A

B1 adrenoreceptors
PKA pathway
phosphorylates Vg Ca
greater contractility

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8
Q

what does PKA also phosphorylate

A

K channels - more effluc
SERCA( calcium ATPase)
greater relaxation

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9
Q

3 things which would reduce the iontropic effect

A

hyperkalaemia
acidic- H+ competes with Ca for TnC binding sites
Hypoxia- effects ion channels

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SEM 1 + 2 CVS (14 decks)

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