sem2: drugs on blood vessels

Question 1

example of ang 2 antagonist (ARB)

Answer 1

losartan

Question 2

example of ACEi

Answer 2

enalapril

Question 3

example of a1 antagonist

Answer 3

prazosin

Question 4

a1 is what g coupled?

Answer 4

Gq because it causes vasoconstriction and is found in VSMCs

Question 5

adrenaline has higher affinity to a1 or B2

Answer 5

B2

Question 6

where is B2 receptors found and what G coupled

Answer 6

skeletal muscle

Gs- since cause constriction via PKA pathway

Question 7

noradrenaline higher affinity to a1 or B2

Answer 7

a1

Question 8

example of a calcium channel blocker

Answer 8

amlodipine

vascular sensitive

Question 9

example of K channel openers

Answer 9

nicorandil

Question 10

example of PDE5 inhibitors

Answer 10

slidenafil

Question 11

what does PDE5 normally do

Answer 11

breakdown cGMP (PKG pathway)

Question 12

3 main agents to prevent vasoconstriction

Answer 12

Gq receptor blockers
Ca2+ influx blockers(CCB, Kopeners)
contractile mechanism relaxants (NO, PDEi)

Question 13

example of ETA receptor antagnoist

Answer 13

Bosentan