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Immunology & Serology > Serology review pt.2 > Flashcards

Serology review pt.2 Flashcards

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1
Q

Combines soluble antigen with soluble antibody to produce Insoluble compact complexes

A

PRECIPITATION

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2
Q

Produced against most proteins and some carbohydrates and carbohydrates-lipid complexes

A

PRECIPITINS

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3
Q

It interferes with the migration of charged particles

A

Agar

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4
Q

Transparent, colorless, neutral gel

A

Agarose

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5
Q

(True or False):

To see a visible reaction, relative concentrations of antigen and antibody must be equal

A

True

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6
Q

(True or False):

IgM is significant in saliva

A

False (IgA)

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7
Q

It makes use of serum wells

A

Radial Immunodiffusion

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8
Q

Antigen or Antibody is adsorbed on an inanimate particle (latex or gelatin)

A

Latex Agglutination / Gelatin Particle Agglutination Test

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9
Q

Uses a petridish

A

Double Gel Diffusion (Ouchterlony)

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10
Q

Swelling of the capsule surrounding a bacterium

A

Capsular Precipitation

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11
Q

To impregnate the capsule with a substance allowing it to become luminous by penetrating through the mucopolysaccharide complex

A

Neufeld / Quellung reaction

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12
Q

Process of separating proteins in a mixture using their different net electrical charges

A

Electrophoresis

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13
Q

(True or False):

Size and Shape in electrophoresis may cause frictional drag

A

True

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14
Q

If electricity is not yet introduced

A

Stationary phase

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15
Q

An adaptation of radial immunodiffusion but faster

A

Rocket immunoelectrophoresis

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16
Q

it means cancer cells are spreading

A

Metastasis

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17
Q

Antigen that caused the cancer have circulated from other parts of the human body to infect other organs

A

Angiogenesis

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18
Q

This is where we get our monoclonal antibodies

A

Hybridoma

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19
Q

Two stages of Agglutination

A

Sensitization & Lattice formation

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20
Q

It is a very good screening and qualitative analysis of antigen or antibody present in human sera

A

Agglutination

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21
Q

These are insensitive and may give non-specific reactions

A

Haemagglutination / Haemagglutination inhibition tests

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22
Q

(True or False):

IgG is the one present in CRP in the first 2-3 weeks upon exposure to infectious material

A

False (IgM)

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23
Q

It utilizes fluorescin-labelled anti-humanantibdoy

A

Immunofluorescence test

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24
Q

Positive reaction of imunofluorescence test

A

Apple-green fluorescence

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25
Best used for the detection of Syphilis because the motile movement of the organism is observed
Immunofluorescence test
26
Rapidly exploding field
Molecular techniques
27
Non-specific protein that appears in serum as response to an inflammatory condition
C-reactive protein
28
A direct and quantitative measure of the acute-phase reactions
C-reactive proteins
29
An extremely elevated CRP is suggestive of a possible _______ infection
Bacterial
30
Parameter for inflammatory activity
CRP
31
(True or False): | CRP is a screening test not a confirmatory test
True
32
Infection in the blood that undergoes replication and multiplication within a short period of time
Septicemia
33
Spirochete agent of Syphilis
Treponema pallidum
34
(True or False) | T. pallidum cannot be cultured
True
35
This method shows a transparent object against a black background
Darkfield Microscopy
36
T. pallidum moves in _____ pattern
circular
37
Through this method, you will see formation of syphilitic antibodies
Fluorescent antibody
38
The gold standard for treponema detection
Venereal disease research laboratory (VDRL)
39
Artificial antigen made up of cardiolipin material
Reagin
40
It is a modified VDRL w/ charcoal particles
Rapid plasma reagin (RPR)
41
___ & ____ enhances flocculation
Cholesterol & Lecithin
42
A confirmatory test that uses slides fixed with Nichols train of T. pallidum
Fluorescent treponemal antibody absorption (FTA-ABS)
43
A screening test that is not as sensitive as FTA
ELISA
44
(True or False): | If a non-treponemal antibody screening test is negative, you must do a specific treponemal antibody test
False | Non-treponemal Ab test should be POSITIVE
45
Which test cannot be performed on CSF or cord blood
Rapid plasma reagin
46
Two types of antibodies found in serologic testing for syphilis
Treponemal | Non-treponemal
47
2 most widely used Non-treponemal serologic procedures
VDRL | RPR
48
Positive result of VDRL and RPR
Aggregates / Clumps
49
What assessment should be made quarterly for 1 year after syphilis treatment
quantitative VDRL
50
Test that can be performed on unheated serum or plasma
RPR
51
It is used for easier detection of visible clumps / aggregates
Charcoal
52
2 Treponemal serologic procedures
Fluorescent treponema antibody absorption (FTA-ABS) | Microhemagglutination treponema pallidum (MHA-TP)
53
(True or False): | FTA-ABS and MHA-TP can be used as primary screening methods
False
54
It uses a killed suspension of T. pallidum as antigen
FTA-ABS
55
This method is obsolete and no longer used
Treponema pallidum immobilization test (TPI)
56
Why is serum inactivated?
To assure that there are no cold agglutinins or IgM
57
This test is read microscopically
VDRL
58
Causative agent of Lyme disease
Borrelia burgdoferi
59
It is also known as "Bull's eye rash"
Lyme disease
60
Most common confirmatory test for Lyme disease
Western blot
61
This organism is seen as cocci in chains
Streptococcus pyogenes
62
Leading cause of Oropharyngitis
Streptococcal infections
63
2 major sites of streptococcal infection
Upper RT | Skin
64
This test suggests recent streptococcal infection
Antistreptolysin O
65
Transient antibodies that appear in patients with M. pneumoniae
Cold agglutinins
66
A human antibody against the Fc portion of immunoglobulin
Rheumatoid factor
67
It is usually found in serum and joint fluid
Rheumatoid factor
68
VZV on adults
Shingles
69
The causative agent of Infectious mononucleosis
EBV
70
This test uses horse RBCs
Monospot
71
Symptoms of this virus resemble Infectious Mononucleosis
CMV
72
It causes lesions ABOVE waist
HSV-1
73
It causes lesions BELOW waist
HSV-2
74
It is the only one that can neutraliza VZV
Acyclovir
75
Single stranded, enveloped RNA belonging to the family Togaviridae
Rubella
76
MMR vaccine is given at __ months
15
77
(True or False:) | IgG declines by 4-5 weeks, but may persist for a year
False (IgM)
78
Rare mass that forms inside the uterus at the beginning of pregnancy
Hydatidiform mole / Teratoma

Immunology & Serology (6 decks)

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