Session 1 Flashcards

(35 cards)

1
Q

What are the 2 semi independent parts of the Lymphatics system?

A

Tissues & organs

Capillaries & vessels

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2
Q

What are the 3 main functions of the Lymphatics system?

A

Defense
Fluid balance
Fat absorption

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3
Q

What is the direction of transport of fluid?

A

From the interstitial spaces to the blood

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4
Q

What is unique about lymphatic vessels?

A

No basement membranes so more permeable.

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5
Q

How are Lymphatic vessels like veins?

A

They have one way valves

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6
Q

How are Lymphatic vessels pressurised?

A

Contraction of skeletal muscle
Smooth muscle in wall
Pressure change in the chest due to breathing.

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7
Q

What are the 2 places that the lymphatic vessels empty in to?

A

Right lymphatic duct

Thoracic duct

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8
Q

What lymph vessels drain into the right lymphatic duct and where does it empty?

A

Upper right limb
Right half of head, neck and chest
Empties into the right subclavian vein

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9
Q

What lymph vessels drain into the thoracic and where does it empty?

A

The rest of the body

Empties into the left subclavian vein

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10
Q

What are the 4 lymphoid organs?

A

Lymph nodes
Tonsils
Spleen
Thymus gland

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11
Q

What are the 2 sections of lymph nodes?

A

Outer section - Cortex (Part follicles and germinal centre with lymphocytes)
Inner section - Medulla (Phagocytic, macrophages)

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12
Q

What fluid components enter into the the blood?

A
Substances from plasma (nutrients, proteins)
From cells (enzymes, waste)
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13
Q

How does the lymphatic system aid fat absorption?

A

Specific lymphatic vessels called lacteals in the small intestine lining. Fat goes to the lymphatic vessels and venous circulation.

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14
Q

What is Chyle?

A

Lymph that is milky in appearance due to fat.

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15
Q

How does the lymphatic system aid defence?

A

Removal of organisms and foreign substances from the lymph to activate the immune system.

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16
Q

What is Lymphadenopathy?

A

All lymph nodes are enlarged

17
Q

What is Lymphadenitis?

A

Swollen, painful node responding to foreign antigen

18
Q

How will a lymph node appear if it is a site for metastic cancer?

A

Usually swollen, firm and painless.

19
Q

How is Tonsilitis caused?

A

Caused by congestion of the lymph tissue around the pharynx (usually trap and remove bacteria) with bacteria

20
Q

What are the 2 tissue types that fill the sinuses in the spleen?

A

Red pulp & White pulp

21
Q

What is in the red pulp of the spleen & how does it work?

A

Red blood cells & Macrophages
It receives arterial blood which passes into venous sinuses. Lined by macrophages to remove old red cells and recycle iron

22
Q

What is in the white pulp of the spleen & how does it work?

A

Lymphocytes
It has T & B cell compartments with macrophages & other immune cells. It will recognise and remove pathogens and activate T & B cells.

23
Q

What happens to the Thymus with age?

A

It is replaced with fat and connective tissue.

24
Q

What does the Thymus produce?

A

T lymphocytes and protein hormones called thymosins

25
Define infection
Invasion of a host's tissue by micro-organisms. The disease is caused by microbes multiplying and releasing toxins or causing a host response.
26
What is a commensal?
Micro organisms on/around of the body which are harmless. They are called pathogens when they become harmful.
27
What are Zoonoses?
Infections naturally transmissible between humans and animals
28
What are the modes of horizontal transmission?
Contact - Direct/Indirect/Vectors Inhalation - Droplets (travel 1m) aerosols (travel further) Ingestion - Faecal oral transmission
29
What are the modes of vertical transmission?
Mother to child (usually before birth)
30
What are virulence factors?
Exotoxins/Endotoxins, Cytolytic, AB toxins, superantigens, enzymes Host cellular damage (Direct due to host immune respone)
31
Define Virulence factors
Molecules expressed and secreted by pathogens to enable them to achieve specific things.
32
Define Inoculum size
Determines the extent of disease
33
What investigations can you do for an infection?
Full blood count C Reactive protein Blood chemistry Imagining
34
What does full blood count look for?
Lymphocytes | Neutrophils (Mainly bacterial infections)
35
When is C Reactive protein used?
In the acute phase of an infection