Session 13 - Treatment of Gastric Disease Flashcards Preview

Semester 5 - Farmocology > Session 13 - Treatment of Gastric Disease > Flashcards

Flashcards in Session 13 - Treatment of Gastric Disease Deck (20)
1

What two ways do you treat GORD and oesophagitis?

- Healing and maintenance
- Treat complications

2

If a patient presents to GP with GORD, what is the treatment algorithim?

Lifestyle -> Antacids -> H2 receptor antagonists -> PPI

3

If a patient presents to hospital with GORD what are the treatment options?

PPI -> H2 Receptor antagonist -> Antacoids
-> Lifestyle modification

4

Give four adverse reactions of PPI

GI upset
Nausea
Headaches
Risk of gastric atrophy

5

H2 Receptor antagonist

Dizziness
Fatigue
Gynaecomsatia
Rash

6

How do you treat h.pylori infection?

PAC
Proton pump inhibitor
Amoxicillin/Clarithromycin
H2 antagonist

For 7-14 days

7

Name a PPI

Omeprazole

8

Give five indications for PPI

Short term treatment of peptic ulcers
Severe GORD
Confirmed Oesophagitis
Eradication of H.pylori
Zollinger Ellinson Syndrome

9

What is zollinger ellinson syndrome

Gastrin Secreting Pancreatic tumour

10

What is the mechanism of action of PPI?

Irreversibly inhibit Na+/K+ ATPase that are responsible for proton secretion from parietal cells

11

What are the adverse drug reactions of a PPI?

GI upset, nausea
Headaches
Risk of gastric atrophy with long-term treatment

12

How do PPIs (omeprazole) interact with other drugs?

CYP450 Enzyme inhibitor
Avoid use in patients being treated with warfarin, phenytoin

13

How long does a PPI take to kick in?

Action delays as not all pumps are active all the time. Maximum efficacy 2-3 days

14

How long does it take to reverse effects of PPI?

Requires a few days

15

Name a H2 antagonist

Cimetidine

16

What are two conditions in which H2 antagonist can be used?

Peptic ulcer disease
GORD

17

What is the mech of action of H2 antagonist?

Competitively antagonise H2 receptors, blocking amplification

18

What are some adverse drug reactions of H2 antagonists?

Dizziness
Fatigue
Gynaecomastia
Rash

19

What are some drug drug intercations of H2 antagonists/

Cyp450 enzyme inhibitor
Avoid in patients with warfarin or phenytoin

20

What are some therapeutic notes for H2 antagonist?

Given at night when acid buffering by food at its lowest