Flashcards in Session 13 - Treatment of Gastric Disease Deck (20)
What two ways do you treat GORD and oesophagitis?
- Healing and maintenance
- Treat complications
If a patient presents to GP with GORD, what is the treatment algorithim?
Lifestyle -> Antacids -> H2 receptor antagonists -> PPI
If a patient presents to hospital with GORD what are the treatment options?
PPI -> H2 Receptor antagonist -> Antacoids
-> Lifestyle modification
Give four adverse reactions of PPI
Risk of gastric atrophy
H2 Receptor antagonist
How do you treat h.pylori infection?
Proton pump inhibitor
For 7-14 days
Name a PPI
Give five indications for PPI
Short term treatment of peptic ulcers
Eradication of H.pylori
Zollinger Ellinson Syndrome
What is zollinger ellinson syndrome
Gastrin Secreting Pancreatic tumour
What is the mechanism of action of PPI?
Irreversibly inhibit Na+/K+ ATPase that are responsible for proton secretion from parietal cells
What are the adverse drug reactions of a PPI?
GI upset, nausea
Risk of gastric atrophy with long-term treatment
How do PPIs (omeprazole) interact with other drugs?
CYP450 Enzyme inhibitor
Avoid use in patients being treated with warfarin, phenytoin
How long does a PPI take to kick in?
Action delays as not all pumps are active all the time. Maximum efficacy 2-3 days
How long does it take to reverse effects of PPI?
Requires a few days
Name a H2 antagonist
What are two conditions in which H2 antagonist can be used?
Peptic ulcer disease
What is the mech of action of H2 antagonist?
Competitively antagonise H2 receptors, blocking amplification
What are some adverse drug reactions of H2 antagonists?
What are some drug drug intercations of H2 antagonists/
Cyp450 enzyme inhibitor
Avoid in patients with warfarin or phenytoin