Flashcards in Session 23 - Urinary III Deck (63):
What can cause hemoglobinuric nephrosis?
Increased circulating hemoglobin in a hemolytic crissi
What can cause hemoglobiuric nephrosis in sheep?
Chronic copper toxicity
What can cause hemoglobiuric nephrosis in cattle?
Leptosporosis + Babesiosis
What can cause hemogloburic nephrosis in dogs?
Babesiosis + AIHA
What can cause hemogloburic nephoris in horses?
Red maple leaf toxicity
By what pathologic mechanism does hemogloburic nephoris occur?
Renal ischemia + Increased serum hemoglobin
Passage of hemoglobin through glomeruli
Intratubular casts of hemoglobin pigment
Compounds tubular epithelial damage
What is the gross appearance of hemogloburic nephrosis?
Gun-metal blue to chocolate color of kidney
What causes myglobinuric nephrosis?
Acute, extensive muscle necrosis
What can cause myoglobinuric nephrosis in wildlife?
What is seen in horses with myoglobinuric nephrosis?
What is another name for acute rhabdomyolysis in horses?
Monday morning disease
What is the pathogensis of myoglobinuric nephrosis?
Similar to hemogloburic nephrosis
Myoglobin seen earlier and more readily in urine
Why is myoglobin seen quicker then hemoglobin?
Smaller, no carrier protein needed
What does lilies cause in cats?
Acute tubular necrosis
What is renal papillary necrosis commonly associated with?
Hypoperfusion of the inner medulla
What commonly causes renal papillary necrosis in equine?
Phenylbutazone or Flunixin meglumine
What commonly causes renal papillary necrosis in dogs and cats
Ibuprofen + Aspirin + Acetominophen
By what mechanism does Acetominophen cause renal papillary necrosis?
Directly damages tubular epithelium
What can make NSAID toxicity worse?
How do NSAIDs cause renal papillary necrosis?
Reduction of prostaglandins which protect the kidney from ischemia
What cell type is responsible for prostaglandin release in teh kidney?
When are uroliths most common in cattle?
Where are stones found most commonly in cattle?
Sigmoid flexure of males
What can exacerbate the effects of uroliths?
What kind of urolith is most common in cattle?
Silica or struvite
What are the two most common uroliths in canines?
Struvites + Calcium oxalate
What is the most common type of urolith in otters?
What bacteria is specific to bovine urinary tracts?
-- and --
What bacteria is specific to the swine urinary tract?
What do the bacteria listed in this lecture tend to cause in the kidney?
Thick, red, rough, granular or exudative mucosa
Dilation of renal pelvis
Ulceration of papilla
Why is the focus of inflammation in the renal pelvis?
What causes leptospirosis?
What species are most affected by lepto?
Cattle + Dogs
What is seen histologically with lepto infecton?
Mononuclear inflammation in interstitium
Chronic interstitial nephritis
What age is most affected by the canine herpes virus?
4 to 6 week old puppies
Where do these puppies tend to get canine herpes virus?
intruterine or neonatal infection
What is seen throughout the kidney with canine herpes infections?
What is seen histologically with canine herpes virus?
Acute tubular necrosis
Intranuclear eosinophilic viral inclusions
What type of hypersensitivity is seen with FIP?
Type 4 - cell mediated
What lesions are seen with FIP?
Pyogranulomatous nephritis secondary to fibrinoid vasculitis
Subcapsular + cortical foci of inflammation centered around blood vessels w/ pools of fibrin
What gross lesions are seen with FIP?
Vascular associated + granular texture
What is a differential that looks similar to FIP?
What is a primary tumor of the kidney?
Renal cell carcinoma
What does renal cell carcinoma look like grossly?
Often hemorrhaging present
What is a paraneoplastic condition of renal cell carcinoma?
Erthropoietin oversecretion resulting in polycythemia
What can be associated with renal cell carcinoma in german shepherds? What is seen grossly?
Lesions will be seen in skin
What animal commonly gets renal cell carcinoma?
What is the most common type of neoplasia in dogs?
Transitional cell carcinoma
What does TCC look like grossly?
Cream colored, raised and contains polypoid mass
Where is TCC most commonly found in the bladder?
Around the trigone
What is the most common type of mesenchymal tumor in the urinary tract?
What is the cell origin of a leiomyoma?
What is the histological pattern of a leiomyoma?
Steaming bundles of smooth muscle cells
What is the gross appearance of a leiomyoma?
Smooth, nodular or bulging
Firm with streaming pattern
Where do leiomyomas form?
Ureter + Urethra + urinary bladder
What is the most common renal tumor in dogs?
Renal cell carcinoma
Which occurs more in dogs and cats primary renal tumors or secondary renal tumors? By how much?
Cats - 7x's
Dogs - 2x's
What are the most common renal metastases in dogs?
What are the most common renal metastases in cats?
What is a common renal tumor in pigs and chickens?
What is the origin of nephroblastoma?
Have mesenchymal + Tubular + Glomerular