Signal Transduction I Flashcards Preview

Week 8- SHANE > Signal Transduction I > Flashcards

Flashcards in Signal Transduction I Deck (15)
Loading flashcards...
1
Q

Are signal transactions slow or quick?

A

The actual extracellular binding may be quick, but may have long lasting effects

2
Q

Where is cortisol made?

A

adrenal gland

3
Q

cortisol, estradiol, and testosterone are all classified as what kinds of secretions?

A

steroids (derivatives of cholesterol)

4
Q

What cells are affected by paracrine signals?

A

nearby cells (local)

5
Q

Are neuronal signals specific?

A

Yes, they are relayed through a nerve fiber to a specific cell- neurotransmitters

6
Q

Why is signal tranduction considered an amplification event?

A

Binding of the first messenger stimulates the release of lots of secondary messengers

7
Q

When do proteins act as binary switches?

A

When the off/on conformation of a protein is dependent on the environment and possibly binding of messengers

8
Q

Which aspect of signal transductions, intracellular or extracellular signaling is faster

A

extracellular

9
Q

Is signal transduction that alters protein function fast or slow compared to the transduction that alters protein synthesis?

A

Yes (seconds to minutes), while proteins synthesis alteration takes (mins- hrs)

10
Q

What kinds of the first messenger receptors are extracellular in nature?

A

cytokine, GPCR, tyrosine kinase (has a large, hydrophilic signal)

11
Q

What kinds of the first messenger receptors are intracellular in nature?

A

steroids (has a small, hydrophobic signal)

12
Q

What effect do antagonist ligands have on receptors?

A

They only work to block the action of the receptor. I.e. they neutralize the receptor so no signal transduction can occur

13
Q

What is the rank of potency for B1 adrenergic receptors

A

Iso >Epi=Norepi

14
Q

What is the rank of potency for B2 adrenergic receptors

A

Iso>Epi>Norepi

15
Q

What is the rank of potency for B3 adrenergic receptors

A

Iso=Norepi> Epi