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Path E3 > Skin > Flashcards

Skin Flashcards

(56 cards)

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1
Q

Macule

A

Flat circumscribed <5mm

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2
Q

Patch

A

Flat circumscribed >5mm

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3
Q

Papule

A

Elevated lesion <5mm

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4
Q

Plaque

A

Elevated lesion >5mm

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5
Q

Pustule

A

Discrete pus filled lesion

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6
Q

Vesicle

A

Fluid filled lesion <5mm

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7
Q

Bulla

A

Fluid filled lesion >5mm

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8
Q

Acute Utricaria

A

Hives

-edematous pruritic wheals

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9
Q

Acute Eczema

A

Pruritic inflammatory erythematous papules and scaly plaques

“The itch that rashes

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10
Q

Acute eczema over time the skin

A

Thickens due to acanthosis

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11
Q

Atopic autoimmune eczema

A

Autoimmune related

Genetic predisposition
Atopic triad of asthma, allergies, and eczema

Children then outgrow it

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12
Q

Allergic contact Eczema

A

Type IV hypersensitivity:

CD4+T lymphocyte mediated

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13
Q

Photoeczematous

A

Abnl reaction to UV

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14
Q

Irritan dermatitis

A

Contact exposure to irritant

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15
Q

Erythema Multiforme

A

Hypersensitivity reaction most often due to medication/drug and certain infections

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16
Q

Clinical features of erythema multiforme

A

Multiple types of lesions with macula papules vesicles with central pallor

Can lead to epidermal desquamation if progresses

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17
Q

Psoriasis is associated with

A

Heart disease and can lead to psoriatic arthritis

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18
Q

Psoriasis is a

A

Autoimmune T cell mediated rxn

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19
Q

Acanthosis

A

Epidermal thickening

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20
Q

Psoriasis histologically

A

Epidermal thickening with increase epidermal cell turnover but lack of maturity

Epidermal hyperplasia
Downward extension of Rete pegs
Parakeratoci scale

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21
Q

Clinically psoarias

A

Erythematous pink and salmon colored plaques

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22
Q

Koehler

A

Induce psoriasis lesion by local trauma

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23
Q

Auspitz sign

Study These Flashcards
A

Punctuate bleeding when overlying scale is removed

24
Q

Impetigo

Study These Flashcards
A

Staph Aureus

Can be strep pyogenes

Contagious—usually kids

25
Impetigo states as ______ and then enlarges with honey colored crust
Small macule often perioral/perinasal
26
Blistering Dermatoses a blistering disease where
vesicles and bullae are primary skin findings Blisters occur at different levels within epidermis
27
Acantholysis
Lysis of intercellular junctions between squamous cells
28
Subcorneal
Superficial epidermis at stratum granulosum: pemphigus foliaceus
29
Suprabasal
Above basal cell | Pemphigus vulgarisms
30
Nonacantholysis
Subepidermal Below DEJ Bulbous pemphigoid with intact intercellular junctions
31
Pemphigus is a type ____ hypersensitivity reaction
II
32
Pemphigus ______ bind to intercellular desmosomal proteins
IgG autoantibodies
33
DIF
Intercellular IgG deposition along keratinocytes cell membrane
34
DIF in pemphigus vulagris
IgG depositions throughout epidermis
35
Pemphigus Vulgaris
raise disease of elderly Mucosal and skin involvement -pressure points Flaccid blister that easily rupee leading to denuded skin
36
Subepidermal nonacantholyis
Roof of blister is full thickness of epidermis
37
Actinic Keratosis/Cheilitis
Red scaly patches on chronically sun exposed skin | -fair skinned
38
Actinic Keratosis histo
Cytologic atypical with hyperplasia of basal cells with overall epidermal thinning Freeze off or chemo topical
39
Benign skin neoplasms
Benign nervous
40
Precancerous/Atypical skin neoplasms
Actinic keratosis | Dysplastic nevi
41
skin Cancer neoplasms
Squamous cell Basal cell carcinoma Melanoma
42
Squamous cell carcinoma forms in
Keratinocytes of epidermis
43
Mutations in squamous cell carcinoma
UV light exposure TP53 Mutation HRAS and Notch receptor mutations
44
SCC other risk factors
HPV Immunosuppressive from organ transplant Arsenic infections Xeroderma pigmentosum
45
SCC begins as _____ then over time
Red scaly plaques Becomes invasive nodule and ulcerated
46
Most common type of skin cancer
Basal Cell carcinoma
47
Basal Cell carcinoma will appear
Red scaly patches and also pearly translucent papules with telangiectasisa Usually on face
48
Basal Cell carcinoma | Arise in
Basal layer of epidermis
49
BCC genetic disorder
Basal cell nevus syndrome with PTCH gene mutation in hedgehog tumor suppressor pathway
50
Melanoma is____ most common
3rd
51
Melanoma signs
Rapid change in size of prior nevus with asymmetry Color change Itching/pain New onset pigmented lesion esp in adults Irregular borders
52
Melanoma color
Red brown black
53
Melanoma borders
Notched in appearance
54
Melanoma flat lesions radial growth
Flat lesions that enlarge
55
Melanoma Nodular lesions connote
Invasion into dermis
56
Vertical growth phase is
Key farce in nature of melanomas

Path E3 (8 decks)

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