Flashcards in Skin Pathology Deck (123)
Where is the mitotic pool in normal skin?
What type of epithelium is the normal epidermis made up of?
stratified keratinising squamous epithelium
What are the granules found in the granular layer?
What is the main feature in prickle cell layer?
How is pigment transfered to keratinocytes from the melanocytes?
Where are the langerhan cells found?
upper and mid-epidermis
What are the 2 layers of the dermis?
What is found in the reticular dermis?
appendage structures- sweat glands and pilosebaceous units
What is hyperkeratosis?
increased thickness of keratin layer
What is parakeratosis?
persistence of nuclei in the keratin layer
What is acanthosis?
increased thickness of epithelium
What is papillomatosis?
irregular epithelial thickening
What is spongiosis?
oedema fluid between squames appears to increase prominence of intercellular prickles
What can develop is the spongiosis is sever?
vesicles filled oedema fluid develop
What are the 4 main reaction patterns of inflammatory skin disease?
What is psoriasiform?
elongation of the rete ridges (the squiggly line of the DEJ)
What is lichenoid?
basal layer damage
Give examples vesiculobullous blistering diseases?
pemphigoid; pemphigus and dermatits herpetiformis
What is the Koebner phenomenon?
new lesions arising at the sites of trauma
How is complement involved in psoriasis?
complement attracts neutrophils to the keratin layer which creates munro microabscesses
How do lichenoid disorders appear?
itchy, flat topped violaceous papules
What disease has irregular sawtooth acanthosis with basal damage?
What are other lichenoid disorders aside from lichen planus?
erythema multiforme and toxic epidermal necrolysis
What is the most common type of pemphigus?
What happens histologically during pemphigus?
loss of integrity of epidermal cell adhesion
What drugs can be used to treat pemphigus?
What causes the loss of integrity of the epidermal cell adhesion in pemphigus vulgaris?
IgG auto-antibodies are made against desmoglien which disrupts the desmosomes and results in acantholysis (loss of intercellular adhesion)
What is acantholysis?
lysis of intercellular adhseion sites
What are the main areas of skin that pemphigus vulgaris affects?
scalp, face, axillae, groin and trunk