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Flashcards in Skin Pathology Deck (123)
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1

Where is the mitotic pool in normal skin?

basal layer

2

What type of epithelium is the normal epidermis made up of?

stratified keratinising squamous epithelium

3

What are the granules found in the granular layer?

keratohyalin

4

What is the main feature in prickle cell layer?

prominent desmosomes

5

How is pigment transfered to keratinocytes from the melanocytes?

dendritic processes

6

Where are the langerhan cells found?

upper and mid-epidermis

7

What are the 2 layers of the dermis?

papillary dermis
reticular dermis

8

What is found in the reticular dermis?

appendage structures- sweat glands and pilosebaceous units

9

What is hyperkeratosis?

increased thickness of keratin layer

10

What is parakeratosis?

persistence of nuclei in the keratin layer

11

What is acanthosis?

increased thickness of epithelium

12

What is papillomatosis?

irregular epithelial thickening

13

What is spongiosis?

oedema fluid between squames appears to increase prominence of intercellular prickles

14

What can develop is the spongiosis is sever?

vesicles filled oedema fluid develop

15

What are the 4 main reaction patterns of inflammatory skin disease?

spongiotic-intraepidermal oedema
psoriasiform
lichenoid
vesiculobullous

16

What is psoriasiform?

elongation of the rete ridges (the squiggly line of the DEJ)

17

What is lichenoid?

basal layer damage

18

Give examples vesiculobullous blistering diseases?

pemphigoid; pemphigus and dermatits herpetiformis

19

What is the Koebner phenomenon?

new lesions arising at the sites of trauma

20

How is complement involved in psoriasis?

complement attracts neutrophils to the keratin layer which creates munro microabscesses

21

How do lichenoid disorders appear?

itchy, flat topped violaceous papules

22

What disease has irregular sawtooth acanthosis with basal damage?

lichen planus

23

What are other lichenoid disorders aside from lichen planus?

erythema multiforme and toxic epidermal necrolysis

24

What is the most common type of pemphigus?

pemphigus vulgaris

25

What happens histologically during pemphigus?

loss of integrity of epidermal cell adhesion

26

What drugs can be used to treat pemphigus?

steroid

27

What causes the loss of integrity of the epidermal cell adhesion in pemphigus vulgaris?

IgG auto-antibodies are made against desmoglien which disrupts the desmosomes and results in acantholysis (loss of intercellular adhesion)

28

What is acantholysis?

lysis of intercellular adhseion sites

29

What are the main areas of skin that pemphigus vulgaris affects?

scalp, face, axillae, groin and trunk

30

How does pemphigus vulgaris appear?

fliud filled blisters which rupture to form shallow erosions-dont really see bullae