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Flashcards in Skin Pathology Rashes Deck (24):
1

Where are langerhans cells located in the skin?

In the upper and mid-epidermis

2

Types of collagen that make up the dermis

Type 1 and type III

3

Where would you find ground substances- hyaluronic acid and chondroitin sulphate

The dermis

4

Type of collagen in reticular dermis?

Type 1

5

This part of the dermis contains appendage structures - sweat glands and pilosebaceous units

Reticular dermis

6

What is the epidermal basement membrane made of?

Laminin and collagen

7

Parakeratosis

Persistence of nuclei in the keratin layer

8

Lichenoid-basal layer damage

Lichen planus
Lupus

9

Spongiotic-intraepidermal oedema

Eczema

10

Munros Microabscess

Cardinal sign of psoriasis!

11

Aetiology of acne

1. Increased androgens at puberty
2. ?? Increased androgen sensitivity of sebaceous glands
3. Keratin plugging of pilosebaceous units
Infection with anaerobic bacterium corynebacterium acnes.

12

Patchy inflammation with which type of cells in Rosacea?

Plasma cells

13

Most common type of pemphigus?

Pemphigus vulgaris

14

IgG auto-antibodies against desmoglein 3?

Pemphigus vulgaris

15

What does desmoglein 3 do?

Maintains desmosomal attachments

16

Intra-epidermal IgG

Pemphigus vulgaris

17

Circulating antibodies (IgG) react with a major and/or minor antigen of the hemidesmosomes anchoring basal cells to basement membrane

Bullous pemphigoid (IgG against hemi-desmosomes in basement membrane)

18

Linear IgG and complement deposited around basement membrane!!

Bullous pemphigoid!!
Remember this is deeper = BM!!
(pemphigus = intraepidermal)

-send early lesions for biopsy, older ones may mimic pemphigus vulgaris

19

Linear BM IgG

Bullous pemphigoid

20

HLA-DQ2

Dermatitis herpetiformis

21

Dermatitis herpetiformis associated with which HLA?

HLA-DQ2

22

Papillary dermal microabscesses

Dermatitis herpetiformis

23

Deposits of IgA in dermal papillae

Dermatitis herpetiformis

IgA antibodies target gliadin component of gluten but cross react with connective tissue matrix proteins

Immune complexes form in dermal papillae and activate complement and generate neutrophil chemotaxins.

24

granular IgA

Dermatitis herpetiformis