Flashcards in Skin Pathology Rashes Deck (24):
Where are langerhans cells located in the skin?
In the upper and mid-epidermis
Types of collagen that make up the dermis
Type 1 and type III
Where would you find ground substances- hyaluronic acid and chondroitin sulphate
Type of collagen in reticular dermis?
This part of the dermis contains appendage structures - sweat glands and pilosebaceous units
What is the epidermal basement membrane made of?
Laminin and collagen
Persistence of nuclei in the keratin layer
Lichenoid-basal layer damage
Cardinal sign of psoriasis!
Aetiology of acne
1. Increased androgens at puberty
2. ?? Increased androgen sensitivity of sebaceous glands
3. Keratin plugging of pilosebaceous units
Infection with anaerobic bacterium corynebacterium acnes.
Patchy inflammation with which type of cells in Rosacea?
Most common type of pemphigus?
IgG auto-antibodies against desmoglein 3?
What does desmoglein 3 do?
Maintains desmosomal attachments
Circulating antibodies (IgG) react with a major and/or minor antigen of the hemidesmosomes anchoring basal cells to basement membrane
Bullous pemphigoid (IgG against hemi-desmosomes in basement membrane)
Linear IgG and complement deposited around basement membrane!!
Remember this is deeper = BM!!
(pemphigus = intraepidermal)
-send early lesions for biopsy, older ones may mimic pemphigus vulgaris
Linear BM IgG
Dermatitis herpetiformis associated with which HLA?
Papillary dermal microabscesses
Deposits of IgA in dermal papillae
IgA antibodies target gliadin component of gluten but cross react with connective tissue matrix proteins
Immune complexes form in dermal papillae and activate complement and generate neutrophil chemotaxins.