skin systmeic disease

Question 1

what can a punch biopsy look at?

Answer 1

neoplasia (histologyy)
immunofluorescence (auto antibodies)
cell cultures

Question 2

what immunological things are seen in SLE

Answer 2

AMA
antiDSDNA
low complement
antiphospholipid

Question 3

skin in SLE?

Answer 3

photodistributes rash
palpable purpura
SCLE
livedoreticularis

Question 4

what is seen in cutaneous lupus?

Answer 4

SCLE
discoid lupus

scarring and ring like plaques

Question 5

what ab is seen in neonatal lupus

Answer 5

ro

Question 6

what should be done if neonatal lupus is suspectred

Answer 6

ECG

can lead to heart block

Question 7

skin features of dermomyositis?

Answer 7

gottrons papules 
ragged cuticles 
shawl sign 
heliotriope rash 
photodistrubuted rash

Question 8

what ab is associated with interstitual lung disease in dermo myositis

Answer 8

anti MDA5

Question 9

investigations for dermomyositis

Answer 9

ANA
CK
biopsy
LFT (ALT is up)
EMG 
malignancy screening

Question 10

what is associated with IgA vasculitis?

Answer 10

abdo pain
gi bleeding
glomerulonephritis

Question 11

what is seen in anchor associated vasculitis

Answer 11

ulcerative rash
granulomatosis
nosebleeds
can be fatal

Question 12

what is sarcoidiosis

Answer 12

granulomatous plaques on organs

Question 13

what does the skin look like in sarcoidosis?

Answer 13

highly variable

Question 14

what must be done for sarcoidosis diagnosis

Answer 14

exclude tb - culture/x rya

Question 15

what is DRESS?

Answer 15

rash and systemic disorder with underlying mechanisms unknown

Question 16

what is DRESS dianosis based on?

Answer 16

fever 
lymphadenopathy (2+ sites)
atypical lymphocyres
hypereosiniphilia
organ involvement
skin involvement (facial oedema)

Question 17

what does the rash look like in dress

Answer 17

papules,
morbilliform eruption
widespread erythema
head oedema

Question 18

how can you tell if a rash is caused by graft vs host?

Answer 18

face involvement
acral involvement
diarrhoea

Question 19

what is th pathogenesis of graft vs host?

Answer 19

donor derived t lymphocye activity against antigens in immunosiuppression

Question 20

investigations for priitus without rash?

Answer 20

fbc, ldh 
renal profile 
lft 
ferratin 
xray chest 
check fpr hiv etc

Question 21

symptoms of scurvy??

Answer 21

spongy gums and bleeding
corkscrew hairs
ptetchiae,
follicular hyperkeratossis

Question 22

what is the triad of symptoms seen in zinc deficiency?

Answer 22

dermatitis
diarrhoea
depression

Question 23

what does b3 deficiency look like

Answer 23

dermatitis 
diarrhoea 
dementia 
death
photodistributed erythema 
casals necklace

Question 24

what is kwashiorkor?

Answer 24

protein deficiency

Question 25

what causes carcinoid syndrome

Answer 25

5-ht secretion by metastatic cancers

Question 26

symptoms of carcinoid?

Answer 26

diarrhoea bronchospasm hypotension

Question 27

prodrome of SJSTEN?

Answer 27

flu like

Question 28

what is the skin lesion like in SJSTEN?

Answer 28

lesions on trunk artthroid skin detachment like wet wallpaper

Question 29

what is SJSTEN

Answer 29

cell mediated cytotoxic reaction against keratinocytes

Question 30

how is SJSTEN assessed?

Answer 30

``` SCORTEN age, hr % epidermal attachment serum urea, glucose malignancy ```

Question 31

how is SJSTEN classified?

Answer 31

sjs < 10% sjs/ten 10-30 ten 30+

Question 32

consequences of skin failure?

Answer 32

``` peripheral oedema tachycardia loss of fluid and protein disturbed thermoregulation sepsis ```

Question 33

cutaneous signs of ckd?

Answer 33

anaemia excoriations calciphylaxis half and half nails

Question 34

cutaneous signs of chronic liver disease

Answer 34

excoriations jaundice terrys nails clubbing

Question 35

what is nectolosis liopoidica?

Answer 35

diabetes mellatus sign | plawues with red brown raised edge, yellow brown centre

Question 36

what is eosiniphillic folliculitis a sign of?

Answer 36

hiv

Question 37

what cutaneous disease are associated with ibd?

Answer 37

pyoderma gangrenosum orofacial granulomatosis celiac - dermatitis herpetiformis

Question 38

what did you maybe get in summer 202-

Answer 38

hudradenititis suppuritiva

Question 39

what is pyoderma gangrinosum

Answer 39

pustule on erythematous base which ulcerates associated with IBD