Small Group: Placenta and Breast Pathology

Question 1

Differentiate the route of infection for chorioamnionitis and villitis.

Answer 1

• Chorioamnionitis usually results from ascending infections from the vagina.
• Villitis usually results from hematogenous spread.

Question 2

There is a ___________ between the amnion and the chorion that is held together by the pressure of the amniotic fluid.

Answer 2

potential space

Question 3

What agents usually cause chorioamnionitis and villitis?

Answer 3

• Chorioamnionitis: bacteria from the vagina (group B Strep. most common)
• Villitis: agents from the maternal blood (ToRCHeS)

Question 4

What immune cells are common in villitis and chorioamnionitis?

Answer 4

• Chorioamnionitis: neutrophils

* Villitis: lymphocytes (VUE), plasma cells (CMV), and neutrophils (Listeria)

Question 5

hCG is more elevated in _______________.

Answer 5

complete molar pregnancies

Question 6

Remember, p57 is only present in _____________ molar pregnancies.

Answer 6

partial (because p57 is maternally expressed)

Question 7

What is VBAC?

Answer 7

Vaginal birth after caesarean section

Question 8

Just for good measure, differentiate placenta accreta, increta, and percreta.

Answer 8

• Accreta: chorion adhered to surface of myometrium
• Increta: chorion burrowed into the myometrium
• Percreta: chorion burst through the serosal layer of the uterus

Question 9

Fibroadenomas typically arise from ____________.

Answer 9

stromal tissue, although they do involve glandular hyperplasia as well

Question 10

What’s the difference between proliferative disease and atypical hyperplasia?

Answer 10

Proliferative disease presents with a regular duct formation pattern, while atypical hyperplasia presents with irregular ducts. Both are benign.