Solid Dosage Forms

Question 1

Intimate mixtures of finely divided drugs or chemicals in dry form which may be used internally or externally

Answer 1

Powder

Question 2

Advantages of Powders

Answer 2

flexibility in compounding
good stability
rapid dispersion of ingredients
relatively dry & devoid of moisture

Question 3

Disadvantages of Powders

Answer 3

Inaccuracy of dose
Not suitable for dispersing deliquescent and hygroscopic drugs
Time consuming Preparation
Not suitable for unpleasant tasting drugs

Question 4

Animal and Vegetable Drugs
Sieve

Answer 4

Very coarse – no. 8
Coarse – no. 20
Moderately coarse – no. 40
Fine – no. 60
Very fine – no. 80

Question 5

Chemical
Sieve

Answer 5

Coarse – no. 20
Moderately coarse – no. 40
Fine – no. 80
Very fine – no. 120

Question 6

Reduction in particle size of solid to a finer state

Answer 6

Comminution

Question 7

Methods of Comminution

Answer 7

Trituration
Levigation
Pulverization by Intervention

Question 8

Reducing particle size with use of Mortar and pestle

Answer 8

Trituration

Question 9

Types of Mortar

Answer 9

Glass
Wedgewood
Porcelain

Question 10

Glass Mortar

Answer 10

Smooth surface
Non-porous
Used for highly colored materials and dyes

Question 11

Wedgewood Mortar

Answer 11

Tough surface
Porous
Used for Crystalline Solids

Question 12

Porcelain Mortar

Answer 12

Tough surface
Porous
Used for soft aggregates and crystals

Question 13

Commonly used in small scale preparation of ointments & suspensions to reduce particle size & grittiness of the added products

Formation of paste by addition of non-solvent (levigating agent)

Answer 13

Levigation

Question 14

Levigating agents

Answer 14

mineral oil
glycerin
propylene glycol

Question 15

Addition of volatile substances to gummy compounds

Answer 15

Pulverization by intervention

Question 16

Camphor + Alcohol
Iodine Crystals + Ether

Answer 16

Pulverization by Intervention

Question 17

Mixing or Blending

Answer 17

Spatulation
Trituration
Geometric Dulution
Sifting
Tumbling

Question 18

Blend small amounts of powders on a sheet of paper/tile
use of spatula; not for potent substances

Answer 18

Spatulation

Question 19

Spatulations is used for mixing

Answer 19

Small amounts of powders
Same densities of powders
Solid substances that liquefy or form eutectic mixtures

Question 20

Involves direct rubbing or grinding of hard powder in a mortar and pestle

Answer 20

Trituration

Question 21

Addition of equal volume of diluent to potent substances

Answer 21

Geometric Dilution

Question 22

Powders are mixed by passing through sifters

Not for potent substances

Answer 22

Sifting

Question 23

This process result in a light, fluffy product and useful for powders that resist mixing by trituration

Answer 23

Sifting

Question 24

A process of mixing powders by shaking or rotating in a closed container

Answer 24

Tumbling

Question 25

This method is used when two or more powders have considerable density differences

Answer 25

Tumbling

Question 26

Classification of Powders

Answer 26

**1. Bulk Powder** * Oral Powders * Dentrifices * Dusting Powders * Douche Powders * Insufflators * Triturations **2. Divided**

Question 27

Finely divided powders or effervescent granules, dissolved in water or mixed with soft foods

Answer 27

Oral Powder

Question 28

Exist in liquid, pwder, or paste form; used for **oral hygiene**

Answer 28

Dentirifices

Question 29

Dentrifices + Fluoride compounds

Answer 29

protect teeth against dental caries

Question 30

Intended to be dissolved in tepid water before use

Answer 30

Douch powders

Question 31

**Antiseptic** or **cleansing agents** for a **body cavity**, commonly used for vagina

Answer 31

Douche Powder

Question 32

Also known as Conspergents

Answer 32

Dusting powder

Question 33

Locally applied non-toxic preparations intended to have **no systemic action**

Answer 33

Dusting powder

Question 34

Finely divided powders, introduced to **body cavities** using **insufflatos** or **powder blower**

Answer 34

Insufflations

Question 35

**Dilution** of **potent drugs** | 1:10 dilutions

Answer 35

Triturations

Question 36

Chartula/Chartulae

Answer 36

Divided Powders

Question 37

Dispensed in **individual doses** usually in folded papers

Answer 37

Divided powders

Question 38

Divided powders are prepared by

Answer 38

* Weighing individuallly * Block and divided method (nonpotent)

Question 39

Types of Powder paper

Answer 39

White Bond Paper – opaque paper with no moisture resistance Glassine Paper – glazed transparent moisture-resistant paper Vegetable Parchment – thin, semi-opaque, moisture-resistant paper Waxed Paper – transparent waterproof paper; suitable for deliquescent and hygroscopic drugs