Tablet

Question 1

Solid dosage form that contain active ingredients & excipients prepared by either molding or compression

Answer 1

Tablets

Question 2

Most common
Most Stable
Most tamper-proof
Dosage form

Answer 2

Tablet

Question 3

Advantages of Tablets

Answer 3

Precision and Low control variability
Low Manufacturing cost
Easy to package and ship
Appropriate for special release form
Simple to identify
Essentially tamper-proof

Question 4

Disadvantages of Tablets

Answer 4

Good compatiblity is required
Resist compression
Requires encapsulation before compression

Question 5

Tablet Types and Classes

Answer 5

Tablets for oral ingestion
Tablets used in oral cavity
Tablets used to prepare solution

Question 6

Tablets formed by compression and in simplest form, contain no special coating

Answer 6

Conventional Compressed Tablets

Question 7

Compressing additional tablet granulation on previosuly compressed granulation

Answer 7

Multiple Compressed Tablets - Layered Tablet

Question 8

Compressing another granulation layer/outer shell around the preformed tablet

Answer 8

Multiple Compressed Tablets: Layered Tablet

Question 9

Compressing another granulation layer/outer shell around the preformed tablet

Answer 9

Multiple Compressed Tablets: Press coated Tablet/Dry coated tablet or Compression Coated

Question 10

Use of Multiple Compressed Tablets

Answer 10

Separate incompatible ingredients
Produce prolonged or repeated release profiles

Question 11

Use of Multiple Compressed Tablets

Answer 11

Separate incompatible ingredients
Produce prolonged or repeated release profiles

Question 12

Compressed talets coated by sugar solution

Answer 12

Sugar Coated Tablet

Question 13

Sugar Coated Tablet

Answer 13

Most elegant solid dosage form
Most difficult and time consuming to produce
50 -100% increase in size and weight

Question 14

Use of Sugar Coated Tablet

Answer 14

To improve appearance
Mask unpleasant taste or smell
Protect from Oxidation

Question 15

Compressed tablets coated w/ a thin layer of a insoluble or soluble polymer

2 - 3% increase in weight

Answer 15

Film Coated Tablets

Question 16

Use of Film Coated Tablets

Answer 16

Protect drug from atmospheric conditions

Question 17

Compressed tablets coated with substances that resist solution in gastric fluid but disintegrate in intestine

Delayed Action tablet

Answer 17

Enteric Coated Tablets

Question 18

Use of Enteric Coated Tablet

Answer 18

To protect the drug which are inactivated destroyed in stomach

Question 19

Enteric coating

Answer 19

Shellac
Cellulose Acetate Pthalate (CAP)

Question 20

Intended to be chewed and swallowed

Answer 20

Chewable Tablets

Question 21

Diluent used in Chewable Tablets

Answer 21

Mannitol

Question 22

Commonly used for multivitamin tablets and for antacids, antibiotics

Answer 22

Chewable Tablets

Question 23

Useful for children and elderly who is hvaing difficulty swallowing

Answer 23

Chewable Tablet

Question 24

Tablets are placed under the tongue and dissolved rapidly

Answer 24

Sublingual Tablet

Question 25

Tablets designed to dissolve slowly in the mouth between the cheek and gingiva

Answer 25

Buccal tablets

Question 26

Use of Sublingual and Buccal tablet

Answer 26

Suitable for drugs that does not absorbed very well in stomach Avoid first pass metabolism

Question 27

Slow dissolving tablet prepared by molding or compression to produce local/systemic effect

Answer 27

Lozenges and Troches

Question 28

Molded Lozenge

Answer 28

pastilles

Question 29

Lozenge + Stick

Answer 29

Lollipop

Question 30

Compressed lozenges

Answer 30

Troches

Question 31

Use of Lozenges and Troches

Answer 31

Better patient compliance Avoide First pass

Question 32

Tablets containing an organic acid and carbonate salt along with API, and dissolved in water

Answer 32

Effervescent Tablet

Question 33

Effervescent tablet composition

Answer 33

Tartaric Acid Citric Acid NaHCO3

Question 34

Advantages of Effervescent Tablet

Answer 34

Improves palatability and faster absorption

Question 35

Tablets containing large amounts of **highly potent drug** substances and supplied for **Extemporaneous Compounding** of the pharmacist

Answer 35

Dispensing tablet/Compounding Tablet

Question 36

Advantages of Dispensing tablet

Answer 36

Can extemporaneously prepared according to requirement of patient

Question 37

Soft, readily soluble tablets, used by physician in preparation of parenteral solution

Answer 37

Hypodermic Tablets

Question 38

Tablets prepared by **molding** and are **very soft** and **disintegrate quickly**

Answer 38

Molded tablet/tablet Triturates

Question 39

Drug product that alter the rate or timing of drug release

Answer 39

Modified Release Dosage Form

Question 40

Abrupt, uncontrolled release of a large amount of drug

Answer 40

Dose dumping

Question 41

Types of Modified Release Dosage Forms

Answer 41

a. Extended release (Controlled release, sustained release) b. Deleayed release c. Repeat Action d. Targeted Release

Question 42

Dosage form that maintains the therapeutic blood or tissue levels of the drug for a prolonged period Provides a prompt-desired effect followed by a gradual release of remaining amount

Answer 42

Extended release

Question 43

Releases the drug at a **constant rate** and provide plasma concentrations that remain invariant with time

Answer 43

Controlled-release | Follows Zero-order

Question 44

Releases an **initial release** of drug sufficient to provide a therapeutic dose after administration, then a **gradual release** over an extended period

Answer 44

Sustained release | Follow first-order Affected by environment

Question 45

Designed to release the drug at a time other than promptly after administration

Answer 45

Deleayed release Dosage Forms

Question 46

Individual dose is released after administration, and second dose is released at intermittent intervals

Answer 46

Repeat Action | 1st dose - Immediate release 2nd dose - delayed release

Question 47

Drug release is direct toward isolation or concentrating a drug in a body, tissue, or site for abs or action

Answer 47

Targeted-release