SOLID DOSAGE FORMS

Question 1

Solid dosage form that may contain only the active drug or a mixture with excipients.

Answer 1

Powder

Question 2

Science of small particles, including measurement and behavior.

Answer 2

Micromeritics

Question 3

Process of reducing particle size (e.g., trituration, pulverization by intervention, levigation).

Answer 3

Comminution

Question 4

Mixing powders with a spatula; not suitable for large quantities.

Answer 4

Spatulation

Question 5

Grinding or mixing powders in a mortar and pestle.

Answer 5

Trituration

Question 6

Mixing potent drug with large diluent by proportionate additions.

Answer 6

Geometric dilution

Question 7

Passing powders through sifters for light, fluffy powders.

Answer 7

Sifting

Question 8

Mixing in large rotating containers.

Answer 8

Tumbling

Question 9

Non-potent powders measured by teaspoon/cup.

Answer 9

Bulk powders

Question 10

Fine powders applied to skin, labeled for external use.

Answer 10

Dusting powders

Question 11

Powders dissolved in water for vaginal use.

Answer 11

Douche powders

Question 12

Powders blown into body cavities (e.g., nose, ears).

Answer 12

Insufflations

Question 13

Medicated powders inhaled using a device (particle size 1–6 µm).

Answer 13

Aerosol powders

Question 14

Dry powder inhaler using drug in blister packs.

Answer 14

Diskhaler

Question 15

Device where capsule is split and powder inhaled.

Answer 15

Rotahaler

Question 16

Single doses wrapped in paper/foil.

Answer 16

Divided powders (Chartulae)

Question 17

Larger particles (sieve size 4–12), prepared by moistening and drying powders.

Answer 17

Granules

Question 18

Contain citric acid, tartaric acid, and sodium bicarbonate; release CO₂ in water.

Answer 18

Effervescent granules

Question 19

Solid dosage form with drug enclosed in gelatin shell.

Answer 19

Capsule

Question 20

Derived from collagen; Type A (acid processed) or Type B (alkali processed).

Answer 20

Gelatin

Question 21

Made of gelatin + excipients; contain 13–16% water.

Answer 21

Hard gelatin capsules

Question 22

Numbered 000 (largest) to 5 (smallest).

Answer 22

Capsule sizes

Question 23

Elastic shells with glycerin/sorbitol; contain liquids, pastes, or suspensions.

Answer 23

Soft gelatin capsules

Question 24

Methods of preparing soft gels.

Answer 24

Plate process, Rotary die process, Reciprocating die process

Question 25

Telescoping (caps sliding), Sweating (moisture issues).

Answer 25

Problems in capsules

Question 26

Solid dosage form prepared by compression/molding with excipients.

Answer 26

Tablet

Question 27

Fillers for bulk (e.g., lactose, starch, MCC).

Answer 27

Diluents

Question 28

Promote granulation and cohesion (e.g., starch paste, glucose solution, gums).

Answer 28

Binders/Adhesives

Question 29

Facilitate breakup in GI tract (e.g., starch, cellulose, clays).

Answer 29

Disintegrants

Question 30

Reduce friction during ejection (e.g., magnesium stearate).

Answer 30

Lubricants

Question 31

Prevent sticking to punches (e.g., talc).

Answer 31

Antiadherents

Question 32

Improve powder flow (e.g., colloidal silica).

Answer 32

Glidants

Question 33

Made by single compression.

Answer 33

Compressed tablets

Question 34

Layered or compression-coated for separation or controlled release.

Answer 34

Multiply compressed tablets

Question 35

Coated for taste, stability, or appearance (heavier).

Answer 35

Sugar-coated tablets

Question 36

Coated with thin polymer film; more durable than sugar-coated.

Answer 36

Film-coated tablets

Question 37

Capsule-shaped tablets for easier swallowing.

Answer 37

Gelatin-coated tablets (Gelcaps)

Question 38

Resist stomach acid, release drug in intestines.

Answer 38

Enteric-coated tablets

Question 39

Dissolve in buccal pouch.

Answer 39

Buccal tablets

Question 40

Dissolve under the tongue.

Answer 40

Sublingual tablets

Question 41

Disintegrate when chewed; often flavored.

Answer 41

Chewable tablets

Question 42

Release CO₂ when dissolved in water.

Answer 42

Effervescent tablets

Question 43

Soft, rapidly dissolving tablets.

Answer 43

Molded tablets

Question 44

Small, cylindrical tablets containing potent drugs.

Answer 44

Tablet triturates

Question 45

Old tablets used for parenteral solution prep.

Answer 45

Hypodermic tablets

Question 46

Formerly used by pharmacists for compounding.

Answer 46

Dispensing tablets

Question 47

Disintegrate without delay.

Answer 47

Immediate-release tablets

Question 48

Dissolve within 1 min in mouth.

Answer 48

Rapidly Disintegrating Tablets (RDTs/ODTs)

Question 49

Dissolve slowly in mouth for local effect.

Answer 49

Lozenges/Lollipops

Question 50

Release drug gradually over time.

Answer 50

Extended-release tablets

Question 51

Compressing powders with good flow/cohesion directly into tablets.

Answer 51

Direct compression

Question 52

Precompressing slugs → grinding → compression.

Answer 52

Dry granulation

Question 53

Uses liquid binder to form granules; not suitable for water/heat-sensitive drugs.

Answer 53

Wet granulation

Question 54

Tablet crown separates.

Answer 54

Capping

Question 55

Splitting into layers.

Answer 55

Lamination

Question 56

Tablet material sticks to punch/die.

Answer 56

Picking/Sticking

Question 57

Uneven color.

Answer 57

Mottling

Question 58

Ability to resist breaking/chipping during handling.

Answer 58

Friability

Question 59

Measures crushing strength.

Answer 59

Hardness test

Question 60

Determines drug release rate.

Answer 60

Dissolution test