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Flashcards in Stomach cells (extra bit) Deck (8)
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1

six cell types

1) simple columnar mucous cells
2) Mucous neck cells
3)undifferentiated stem cells
4) Parietal cells
5) Chief cells
6) enteroendocrine

2

Simple columnar mucus cells

surface and pits. Secrete;
1) mucous coat (traps HCO3- from parietal cells= protective barrier)
2) enriched phospholipid in membrane barrier?????
3) UD stem cells: that migrate and replace surface cells

3

how can the mucous coat be degraded

Helicobactor Pylori
1-urease of bacteria convert
urea>ammonia which degrades mucous coat
2- toxins damage epithelium
- Ulcerogens (PAF)

4

Prostoglandins

Protective, stimulates mucous and phospholipid production.
Especially E2

5

Mucous neck cells

Soluble acidic alycoproteins secreted when food present

6

Parietal cells

-HCl
1) sterilise food
2) acidify environment (chief cell pepsinogen > pepsin) cleaves proteins

-Intrinsic Factor (B12 absorption)

7

less HCl means

less digestion(pepsinogen not cleaved)
less bacteria kill (gastroenteritis)

8

Vitamin B12 important for

RBC haematopoiesis.
Low parietal cell activity > low IF > pernicious anaemia