Straight up antibiotics Flashcards
(34 cards)
Mode of action: disrupt the phospholipoprotein membrane
mode of action polymyxins polyenes Azoles
Voriconazole
disrupt the phospholipoprotein membrane DOC for systemic mycosis, especially aspergillosis in AIDS patients Crosses BBB
Triazoles
disrupt the phospholipoprotein membrane Examples are Fluconazole (diflucan) and Voriconazole
Polymyxin E (colistin)
disrupt the phospholipoprotein membrane i. In Thayer-Martin Chocolate Agar ii. Treats otitis externa
Polymoxins
disrupt the phospholipoprotein membrane isolated from bacillus amphithatic Examples are polymyxin B and Polymyxin E (aka colistin)
Pencillins
Young G+ only (G+ have more murein) - G+ have higher internal pressure so breakdown of murein is drastic Examples are natural penicillins repository penicillins semi-synthetic penicillins Beta lactamase penicillins
aspergillosis
disrupt the phospholipoprotein membrane causes systemic mycosis dimorphic fungi in immunodifficent patients at 25*C looks like mold at 37*C looks like yeast
Fluconazole (diflucan)
disrupt the phospholipoprotein membrane DOC for deep or superficial Candidias
Mode of Action: suppress cell wall synthesis
mode of action penicillins cephalosporins carbapenems bactracin vancomycin
Natural penicillins
naturally occuring examples are benzyl penicillin (G) and phenoxymethyl penicllin (V)
Polyenes
disrupt the phospholipoprotein membrane toxic come from streptomyces treats fungal infections inhibits sterols Examples are Nustatin and Amphotericin B
Amphotericin B
disrupt the phospholipoprotein membrane i. Passes through BBB ii. IV if infection is serious iii. DOC for systemic mycosis caused by aspergillosis
Polymyxin B
disrupt the phospholipoprotein membrane i. Treats resistant actinobacter, otitis externa, ophthalmic infections ii. In triple antibiotic ointment iii. G- only iv. Toxic (Nephro/neurotoxin)
Azoles
disrupt the phospholipoprotein membrane Examples: Imidazoles Triazoles
Imidazoles
disrupt the phospholipoprotein membrane attack sterols Examples are clotrimazole, miconazole, and ketoconazole
Clotrimazole and Miconazole
disrupt the phospholipoprotein membrane Treats ringworm, athlete’s foot, volvovaginits (epidermopyton, microsporum, trichophyton)
Nystatin
disrupt the phospholipoprotein membrane i. Treats dermatophytic (superficial) candidas albicans (thrush, vulvovagitis) Is a polyene
mode of action polymyxins polyenes Azoles
Mode of action: disrupt the phospholipoprotein membrane
disrupt the phospholipoprotein membrane DOC for systemic mycosis, especially aspergillosis in AIDS patients Crosses BBB
Voriconazole
disrupt the phospholipoprotein membrane Examples are Fluconazole (diflucan) and Voriconazole
Triazoles
disrupt the phospholipoprotein membrane i. In Thayer-Martin Chocolate Agar ii. Treats otitis externa
Polymyxin E (colistin)
disrupt the phospholipoprotein membrane isolated from bacillus amphithatic Examples are polymyxin B and Polymyxin E (aka colistin)
Polymoxins
Young G+ only (G+ have more murein) - G+ have higher internal pressure so breakdown of murein is drastic Examples are natural penicillins repository penicillins semi-synthetic penicillins Beta lactamase penicillins
Pencillins
disrupt the phospholipoprotein membrane causes systemic mycosis dimorphic fungi in immunodifficent patients at 25*C looks like mold at 37*C looks like yeast
aspergillosis
