summary from rafi fc Flashcards

1
Q

A band

A

myosin + overlapping actin

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2
Q

H band

A

within A, actin doesnt reach

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3
Q

I band

A

actin which isnt part of A

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4
Q

epimysium

A

whole muscle

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5
Q

perimysium

A

single fasicle

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6
Q

endomysium

A

single muscle fibres

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7
Q

simple synovial joint

A

one pair of articular surfaces

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8
Q

what are chondrocytes responsible for

A

EC matrix of hyaline cartillage T2

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9
Q

what causes septic arthriits

A

staph aureus

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10
Q

how to treat septic arthits

_ in a child

A

fluclox

child < 5 + cefriaxone for H. influenza / kingella cover

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11
Q

which bugs cause OM

A

mycoplasma, pseudomonas, salmonella, brucella (goat’s milk)

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12
Q

how to treat NF

A

penicillin + clindamycin

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13
Q

process behind DMD

A

alterations in anchorage of actin skeleton to basement membrane (fibres weakend without attachemnt)

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14
Q

what is enchondroma associated with

A

olliers + maffuci

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15
Q

what actually is enchondroma

A

hyaline cartilage arising in medullary cavity

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16
Q

what is LEMS

A

assoc with muscle weaenss + small cell carcinoma
arises from antibodies against Ca channels, causing reduced Ca entry + this reduced ACh vesicle release (which is needed to initiate muscle cell)

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17
Q

A nociceptor

A

fast / initial pain

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18
Q

C nociceptor

A

second / aftermath pain

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19
Q

what does spinothalamic tract do

A

pain perception (where it is and how bad)

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20
Q

what does spinoreticular tract do

A

autonomic / emotional response = fear of pain

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21
Q

what does carbimazepine do

A

blocks Na channels, useful of neuromytonia

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22
Q

anti phospholipid antibodies

A

anticardiolipin
lupus anticoagnulant
anti beta 2 glycoprotein

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23
Q

what actually is sjrogens

A

autoimmune destruction of exocrine glands

RO and LA

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24
Q

what actually are systemic sclerosis

A

autoimmune inflammation + thickening due to increased collagen deposition

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25
what are the symptoms of limited systemic sclerosis
CREST | calconosis, raynauds, eosophageal dysmotility, sclerodactyl, talangectasia
26
antibodies of poly / dermatomyosisits
anti jo 1 | ANA
27
treatmnet of polymyalgia rheumatica
15mg predisolone
28
is there muscle weakness in dermatomyosiits
no muscle weakness
29
SLE gene
HLA DR3
30
type of reaction of SLE
T3
31
antibody for SLE
anti - smith (very specific)
32
symptoms of GCA
carotid bruit
33
symptoms of polyarteritis nodosa
vessel bifurcation , hep B
34
how to treat large vessel vasculitis
40-60mg predisolone
35
GPA panca or canca
cANCA
36
symptoms of GPA
saddle nose middle aged men palpable purpura
37
how does methotrexate work
folate antagonist
38
what is spondylolisthesis
forward slippage of one vertebrae onto another
39
what is spondylolysis
defect in pars interarticulars of vertebrae
40
pain going down stairs?
PCL
41
what is OA dissecans
an area of the surface of the knee loses its blood supply + cartilage, sometimes causing bone to fragment off
42
what is pes cavus
fixed plantar flexion of the forefoot
43
tendinitis
inflammation resulting from microtears
44
tendinosis
degeneration of collagen from chronic overuse
45
mallet toe
DIP fixed
46
hammer toe
PIP fixed
47
what is cellulitis caused by
B-haemolytic strep + staph
48
1st line investigation for roataor cuff pathology
USS
49
osteochrondroma chance of malignancy
1% change of malignant transformation
50
what does enchondroma look like on xray
leucent but can undergo mineralisation with a patchy sclerotic appearance
51
what does osteoid ostemoa look like on xray
small nidus of immature bone surrounded by an intense sclerotic halo
52
what is brodies abscess
subacute OM, lyitc lesion on xray
53
malignancy rate of osteosarcoma
10% have pulmonary mets at diagnosis
54
which defect of colalgen is osteogenesis imperfecta
T1
55
how to treat transient synovitis
NSAIDS
56
what is most common cause of child hip pain
transient synovitis
57
what happens in impingement syndrome
tendons of rotator cuff are compressed in the tight acromium space during movement - producing pain
58
how to treat impingement syndrome
subacromial decompression
59
DAB
dorsal interossei - abduction
60
PAD
palmar inteossei - adduction
61
definition of a knee dislocation
rupture of all ligaments
62
nerve and artery at risk in a shoulder dislocation
axillary nerve + artery
63
how to repair recurrent dislocations
bankart lesions
64
what is at risk in a humeral shaft fracture
radial nerve + brachial artery
65
what is a high risk with a scaphoid fracture
ANV
66
what are the 2 intracapsular fractures
femoral head and femoral neck
67
what are the 2 extracapsular fractures
intertrochanteric | subtrochanteric
68
which is worse intra or extra capsular
intra
69
compression injury salter harris 4
intraarticular salter harris 3+5
70
where do simple bone cysts arise from
growth defect from the physis
71
most common place to find osteosarcoma
knee
72
seropositive arthritiis
``` RA lupus scleroderma vasculitis sjrogens ```
73
seronegative arhtiris
anky spondyl psoriatic reactive enteric
74
mixed CTD antibody
anti-RNP
75
myositis antibody
anti jo 1
76
back change in ankyl spondy
increased thoracic kyphosis
77
xray changes on anky spondyl
sclerosis / fusion of SI joints syndesmophytes bamboo spine
78
treatment for ankyl spondyl
NSAIDS physio anti-TNF
79
crystals in pseudogout
calcium pyrophosphate
80
what does chondrocalcinosis mean
depositino of calcium pyrophosphate crystals in cartilage in absence of acute inflammation
81
are complement levels high or low in SLE
low
82
what is the process behind sjrogens
excess collagen deposition
83
does PR pain improve with movement
yes
84
what is a poor prognostic factor of PM
dysphagia
85
which treatment for fibromyalgia
amitriptaline + gabapentin
86
age of GCA
>50
87
how to treat ANCA +
IV steroids + cyclophsophamide (immune suppressor)
88
is HSP ANCA + or -
negative
89
which Ig is associated with HSP
IgA
90
what actually happens in DDH
dislocaiton / subluxation of femoral head during perinatal period
91
what is perthes
idiopathic osteochondritis of the femoral head causing necrosis + abnormal growth boys 4-9
92
what is SUFE
pain in knee
93
treatment for SUFE
pin femoral head to avoid slippage
94
nerve at risk in hip joint problems
obturator nerve
95
what kind of meniscal tear is bucket handle
longitudinal
96
what test to do for meniscal tear
steimanns
97
treatment for hallux ridigus
arthrodesis | allerviates pain but reduced motion
98
where does the tibialise tendon insert into
navicular bone
99
investigatoin for cauda equina
urgent MRI to determine level of prolapse | disectomy follows
100
which probelms is carpal tunnel assocaited with
``` RA pregnancy diabetes renal fialure colles fracture ```
101
tinnels test
percussion over median nerve
102
phalens test
upside down prayer
103
in proximal humeral fractures, which way does the humeral shaft displace
medially due to the pull of pectoralis major
104
what is a nighstick fracture
fracture of ulnar shaft
105
what is bartons frcature
intra articular fratcure of distal radius where carpal bones sublux
106
how many degrees of angulation can be tolerated in a boxers fracture
45
107
which nerve damage can be caused by proximal tibia lfracture
common fibular nerve
108
common fibular nerve damage does
foot drop
109
what is a pilon fracture
distal tibial fracture (intraarticular)
110
what is a lisfranc fracture
fracture of the base of 2nd metatarsal with/without dislocation of the other metatarsals at the TMJ