T4 Metabolism Flashcards
(105 cards)
What is a plasma glucose level of 2.5 mM?
Life threatening low
What do odd chain fatty acids require for oxidation?
Vitamin B12
Name the enzymes of the irreversible reactions of the TCA cycle.
Citrate synthase, isocitrate dehydrogenase, keto-glutarate dehydrogenase
Describe stearic acid.
Unsaturated fatty acid with 18 carbons
What % of 16-24 yo drink at least once a week?
50%
When is glycerol converted to glucose and how?
In starvation by gluconegenesis
Which hormone inhibits glycolysis and when?
Insulin in fed state, or during exercise
How have alcohol related admissions changed from 2000-2010?
Doubled
How soon after lung cancer diagnosis does death occur in half of diagnoses?
6 months
How many UK adults have alcohol dependance?
1.5 million
How what will be produced from complete oxidation of a fatty acid of length 16C?
8 acetyl CoA, 7NADH, 7FAD
What is formed from metabolism of ketogenic amino acids?
Acetyl CoA —-> Fat or CO2 and H2O
How much glucose in there in the blood usually?
10g
When is galactose isomerised to glucose?
When attached to UDP
What is the fate of pyruvate in aerobic conditions?
Decarboxylation and entry into TCA cycle
What does ATP in reactions?
Alters position of equilibrium
How much glucose is stored in the body in the fed state, how much of this is in the liver?
400g, 100g in the liver
What % of premature deaths are due to low fitness?
16%
How are odd-chain fatty acids broken down?
Using acetyl CoA and propionyl CoA
What is produced in the link reaction?
CO2
What is long term quit rate?
25%
What are coenzymes?
Organic groups attached to enzyme that are necessary for its operation
Which reaction produces GTP?
Succinyl-CoA to succinate
What % of LSE groups smoke?
65%