Teratogens Flashcards Preview

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Flashcards in Teratogens Deck (13):
1

Most commonly used teratogen

Ethanol

2

Ethanol side effects? 3

1. Mental retardation
2. ASD
3. Head and face abnormalities

3

Thalidomide effects? 2

Shortened limbs (phocomelia) (Tha-limb-domide)
Represses WNT pathway

4

Phenytoin (Dilantin) effects? 4

1. Digit hypoplasia
2. Cleft lip/palate
3. Microcephaly
4. Fetal Hydantoin syndrome

5

Methotrexate (folic acid antagonist) 4

1. Neural tube defects
2. Clefts
3. GU defect
4. CV defect

6

Androgens effect? 3

1. Low birth weight
2. Males have longer fourth fingers
3. Females have longer second finger

7

Warfarin/Coumadin effect? 3

1. Hypoplastic nose
2. Stippled epiphyses
3. Eye problems

8

Accute/Isotetinoin 3

1. Face
2. CNS
3. CV

9

ACE inhibitors

Renal defects

10

Cocaine 4

1. Premature delivery
2. Placental abruption
3. ADD
4. Fetal addiction to cocaine

11

DES 3

1. Vaginal adenosis
2. Vagina clear cell adenocarcinoma
3. Mullerian anomalies

12

Iodine absence 2

1. Congenital goiter
2. Hypothyroidism

13

Maternal diabetes 3

1. Fetal hyperinsulinemia
2. Hypertrophy of pancreatic islets
3. Fat