WBC Disorders: Pathoma Flashcards Preview

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Flashcards in WBC Disorders: Pathoma Deck (28):
1

All WBC's involve a maturation from what progenitor cell

CD34 hematopoietic stem cell

2

Two stem cells the CD34 hematopoietic stem cell can become?

1. Myeloid stem cell
2. Lymphoid stem cell

3

Myeloid stem cell will form what four blast cells

1. Erythroblast
2. Myeloblast
3. Monoblast
4. Megakaryoblast

4

Erythroblast forms what

RBC's

5

Myeloblast forms what?

1. Neutrophils
2. Basophils
3. Eosinophils

6

Monoblasts form what

Monocytes

7

Megakaryoblasts form what?

Megakaryocytes

8

Lymphoid stem cells will form what two types of blasts?

B lymphoblast
T lymphoblast

9

B and T lymphoblasts will form what?

Naive B and T cells

10

Naive B cells form what?

Plasma cells

11

Naive T cells form what?

CD8 and CD4 T cells

12

Cells mature where?

Bone marrow

13

WBC normal count is what

5 to 10 thousand

14

What is a low WBC count? What is it called?

Less than 5
Leukopenia

15

What is a high WBC count? what is it called?

Leukocytosis

16

A low or high WBC count is usually due to what?

Decrease or increase in one particular cell lineage

17

Two types of leukopenia

Neutropenia
Lymphopenia

18

Neutropenia causes? (2)

1. Drug toxicity
2. Severe infection

19

Drug toxicity has what effect on neutrophils?

Destroys their stem cells

20

Severe infection causes neutropenia why?

Neutrophils move into tissues and are no longer counted in blood

21

Treatment for neutropenia?

GM-CSF or G-CSF to boost granulocyte production

22

Lymphopenia causes? 4

1. Immunodeficiency
2. high cortisol state
3. Autoimmune destruction
4. Whole body radiation

23

Examples of immunodeficiency causing lymphopenia (2)

1. DiGeorge
2. HIV

24

High cortisol state is caused by what? (2)

1. Cushing syndrome
2. Exogenous corticosteroids

25

Example of autoimmune destruction

SLE

26

Whole body radiation is special in regards to lymphopenia why?

Lymphopenia is earliest change after whole body radiation

27

5 types of leukocytosis

1. Neutrophilic leukocytosis
2. Monocytosis
3. Eosinophilia
4. Basophilia
5. Lymphocytic leukocytosis

28

3 causes of neutrophilic leukocytosis

1. Bacterial infection
2. Tissue necrosis
3. High cortisol state