Flashcards in WBC Disorders: Pathoma Deck (28):
All WBC's involve a maturation from what progenitor cell
CD34 hematopoietic stem cell
Two stem cells the CD34 hematopoietic stem cell can become?
1. Myeloid stem cell
2. Lymphoid stem cell
Myeloid stem cell will form what four blast cells
Erythroblast forms what
Myeloblast forms what?
Monoblasts form what
Megakaryoblasts form what?
Lymphoid stem cells will form what two types of blasts?
B and T lymphoblasts will form what?
Naive B and T cells
Naive B cells form what?
Naive T cells form what?
CD8 and CD4 T cells
Cells mature where?
WBC normal count is what
5 to 10 thousand
What is a low WBC count? What is it called?
Less than 5
What is a high WBC count? what is it called?
A low or high WBC count is usually due to what?
Decrease or increase in one particular cell lineage
Two types of leukopenia
Neutropenia causes? (2)
1. Drug toxicity
2. Severe infection
Drug toxicity has what effect on neutrophils?
Destroys their stem cells
Severe infection causes neutropenia why?
Neutrophils move into tissues and are no longer counted in blood
Treatment for neutropenia?
GM-CSF or G-CSF to boost granulocyte production
Lymphopenia causes? 4
2. high cortisol state
3. Autoimmune destruction
4. Whole body radiation
Examples of immunodeficiency causing lymphopenia (2)
High cortisol state is caused by what? (2)
1. Cushing syndrome
2. Exogenous corticosteroids
Example of autoimmune destruction
Whole body radiation is special in regards to lymphopenia why?
Lymphopenia is earliest change after whole body radiation
5 types of leukocytosis
1. Neutrophilic leukocytosis
5. Lymphocytic leukocytosis