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Flashcards in Terminal Respiration Deck (16):
1

Where does the citric acid cycle occur?

Mitochondria

2

What does the CAC make?

3NADH, 2CO2, 1FADH2 and 1 GTP

3

What happens to the NADH and FADH2?

They feed into the electron transport chain

4

How does NADH not formed in the mitochondrial matrix get transported to it from cytoplasm?

Glycerol phosphate shuttle

NADH passes electrons on to G-3-P which enetrs the mitochondria and passes electrons on to FAD to make FADH2.

5

How many steps in the chain?

4

6

Step 1 of the electron transport chain?

NADH-Q Oxioreductase enzyme- oxidises NADH and passes electrons to ubiquinone forming ubiquinol.

Also pumps protons across the intermembranous space

7

Step 2 of the chain?

Succinate-Q reductase

Oxidises FADH2 and passes electrons on to Ubiquinone becoming ubiquinol

8

Step 3 of the chain?

Q-cytochrome c oxioreductase

Takes electrons from 1 ubiquinol molecules and passes them to 2 cytochrome c molecules.

Also pumps protons out into intramembranous space.

9

Step 4 of the chain?

Cytochrome c oxidase

Takes electrons from cytochrome c and passes them to oxygen

Pumps protons

10

What is the other name for ubiquinol?

Q10/Coenzyme 10

11

What does the pumping of protons do?

Sets up a proton gradient across the inner membrane of mitochondria

12

Why is this gradient important?

Because when protons try to follow their gradient back into the mitochondria - ATP synthase uses them to turn ADP to ATP.

13

What is the binding change mechanism

The mechanism by which ATPSynthase uses protons to form ATP

14

NADH provides more pumped protons than FADH2 - true or false?

True - FADH2 only enters in second step so less pumped protons

15

What does it mean if the chain is a coupled process?

ATPase and chain are coupled - if the protons could move across the membranes themselves it would be uncoupled and no ATP made. Results are energy forming heat.

16

What is malignant hyperthermia?

When leaky mitochondrial membranes cause uncoupling - excess heat causing irreversible muscle damage