What are the functions of the skeletal system?
Support: attach ligaments and tendons
Protection: enclose organs in cranial and thoracic cavities
Assistance in Movement
Mineral Homeostasis: stores minerals like calcium and phsophate
Blood Cell Reproduciton: red bone marrow makes red and white blood cells
Triglyceride Storage: Medullary Cavity, in yellow bone marrow
What are the 4 structures of bones?
Long Bone
Flat Bone
Short Bone
Irregular Bone
What are the 2 parts of the long bone?
Diaphysis: shaft
Epipysis: ends
What is the Periosteum?
membrane wrapping around bone, but not bone
What is the Medullar Cavity?
Hollow passage way through middle of bone
where yellow bone marrow is found
What is the Endosteum?
It lines the cavitys inside bone
What are the 4 types of cells in bone tissue?
Osteogenic
Osteoblasts
Osteocytes
Osteoclasts
Osteogenic Cells
found on surface of bone and in the periosteum
capable of mitotic division
Osteoblasts
bone forming cells
found at the margins of the bone
Osteocytes
Mature bone cells
found in lacunae
Osteclasts
bone-dissolving cells
contain many nuclei
what is the Bone Matrix comprised of?
Collagen Fibers
Hydroxyapatite: calcium and phosphate
25% water
50% salts
25% fibrous proteins
Hematopoiesis occurs in…
the spongy bone of long bones
stimulated by, Hematopoietin: hormone that stimulates blood cell formation
Ossification/Osteogenesis
The formation of bone on a connective tissue base
Embryo Skeleton
mostly cartilage, slowly replaced by bone
What are the 2 possible ways of Ossification?
Intramembranous Ossification
Endochondral Ossification
Intramembranous Ossification
bones originate within a sheet-like connectvie layer of tissues
broad, flat bones (skull bones, except the mandible)
Endochondral Ossification
bones begin as hyaline cartilage
form models for future bones
most bones of the skeleton
Stages of Endochondral Ossification
formation of bone collar
cavitation of the hyaline cartilage
periosteal bud invasion and spongy bone formation
medullary cavity formation, secondary ossification centers appear
ossification of epiphyses, hyaline cartilage only reamins in epiphyseal plates
Functional Zones in long bone growth
Growth Zone: epiphyses pushed away from diaphysis
Transformation (calcifcation) Zone: matrix becomes calcified
Ossification Zone: new bone formation occurs
Bone Growth and Remodeling
cartilage continually grows/is replaced by bone
bone is resorbed and added by appositional growth
Hormonal Regulation of Bone Growth
Children/Infants: epiphyseal plate activity stimulated by growth hormone
Puberty: testosterone and estrogen promote growth spurs, and masulinization/feminization of specific parts of skeleton
Later: growth spurts end through epiphyseal plate closure
Bone Deposition
occurs where bone is injured or weak
Vitamins required for Bones
Vitamin C: collagen fiber production
Vitamin A: promote activities associated w/ osteoblasts and osteoclasts
Vitamin D: to absorb calcium from food in small intestines