Test 3 Review Notes Flashcards
___promote growth
proto oncogenes
___ supress growth
tumor suppressor genes
what are the 4 main factors of CA cells
immortal, dysregulated cell growth, change in morphology, change in cell behavior
what phase does gene mutation occur
initation
what are the 4 phases of CA cells
initiation, promotion, progression, metastasis
where does latency occur in the phases of the CA cell
between initiation and promotion
what do tumor promoters do
shorten the latency period
BRCA1 is ER + or -
-
BRCA 2 is ER + or -
+
and adenoma originates where
glandular tissue
a carcinoma originates where
epithelium
a sarcoma originates where
connective
a lymphoma originates where
lymphatic tissue
glioma orriginates where
brain
CA cells have increased or decreased methylation
increased
transformation of one mature cell type to another is
metaplasia
increase in number of cells is
hyperplasia
dedifferentiation/regression of cells is
dysplasia
regression with irregularity of cells is
anaplasia
what does endostatin do
prevent angiogensis in CA
what does MTX do
prevent cell replication in CA
what part of the cell cycle does growth and differentiation occur
G1
what part of the cell cycle does DNA synthesis occur
S
what part of the cell cycle does the cell prepare for duplicaton
G2
