Test 5 Antiinflammatory, arthritis shi Flashcards
(13 cards)
What are some antiinflammatory and arthritis agents ?
Corticosteroids
Antihistamines
Immune modulating agents
OTC antiinflammatory drugs
Saicylates
Block inflammatory response
Antipyretic
Analgesic
Salicylate drug examples
Aspirin
Balsalazide
Choline magnesium trisalicylate
Mesalamine
Olslazine
Salsalate
Salicylate contraindications
Bleeding abnormalities
Impaired renal function
Surgery or invasive procedure scheduled within 1 week , pregnancy or lactation
Adverse effects of salicylate
Result of the direct effects on stomach and clotting systems
Salicyalate toxicity
Drug interactions of salicylates
Interaction with many other drugs
Alterations in absorption
Effects on liver
Therapeutic actions of NSAIDS
Block COX 1 and COX 2
Contraindications of NSAIDS
Celecoxib is contraindicated in presence of allergy to sulfonamides
Bleeding
Preg/ lact
Renal or hepatic dysnfunction
Adverse effects of NSAIDS
GI
Nausea, dyspepsia, GI pain, const, diarrhea, GI bleeding
CNS: Dizziness, somnolence, fatigue
Platelet inhibition
HTN
Bone Marrow depression
NSAID examples
Ibuprofen
Acetaminophen (not really)
Antiarthritis agent examples
Gold compounds: Auranofin
DMARDS:
Tumor Necrosis Factors
DMARDS
May be used early in treatment because it alters course of inflammatory process
TNF blockers
Act to decrease effects of TNF to slow inflammatory response and associated joint damage
Indicated for treatment of RA
Contrainindicated in: Acute infection, cancer, sepsis, tuberculosis, hepatitis, nyelosuppression, preg, heptatic or renal disorders, heart failure, latex allergy
Box warning for risk of serious to fatal infections and the development of lymphomas and other cancers; MI, heart daulure, hypotension
