Th - Biomarkers for MS

Question 1

What is a biomarker?

Answer 1

A characteristic that is objectively measured and evaluated as an indicator of a biological process

Question 2

Where are the oligoclonal bands in MS? CSF or serum?

Answer 2

CSF

Question 3

What is NfL in Multiple Sclerosis? (meaning)

Answer 3

Neurofilament light

Question 4

When do NfL levels increase? Why?

Answer 4

When the axons are damaged, because it’s part of the axonal skeleton

Question 5

Where is NfL detectable? CSF or serum?

Answer 5

Both

Question 6

Can NfL be detected with ELISA?

Answer 6

No, only with high-sensitive techniques

Question 7

Serum NfL (decreases/increases) with disease severity (MS)

Answer 7

Increases

Question 8

Is an increase of NfL specific to MS?

Answer 8

No

Question 9

What is GFAP? (meaning)

Answer 9

Glial Fibrillary Acidic Protein

Question 10

What is GFAP? (explain simple)

Answer 10

Part of the skeleton of astrocytes

Question 11

What is GFAP a hallmark for? (MS)

Answer 11

An astrogliosis scar in MS

Question 12

What line of treatment is Natalizumab?

Answer 12

Second line

Question 13

What line of treatment is Fingolimod?

Answer 13

Second line