We- Resolution of neuro-inflammation

Question 1

What can be said about the location of white matter lesions in RRMS compared to SPMS?

Answer 1

RRMS is more on the inside lesions, SPMS more on the outside.

Question 2

When does an inflammatory response become chronic?

Answer 2

If the natural process to resolve inflammation is not properly functioning

Question 3

What kind of mediators resolve inflammation? (general group)

Answer 3

Lipids

Question 4

What do choroid plexus epithelial cells do?

Answer 4

Make Cerebral spinal fluid

Question 5

Can immune cells come into cerebral spinal fluid through choroid plexus epithelial cells?

Answer 5

Yes

Question 6

Where are specialised pro-resolving lipid mediators produced in the brain?

Answer 6

In the choroid plexus

Question 7

Why are MS patient derived T cells less responsive to specialised pro-resolving lipid mediators?

Answer 7

Because there are less receptors on the T cells of the MS patients that the lipids can engage with.