Thrombopoiesis

Question 1

CFU-GEMM → CFU-Meg →

Answer 1

Megakaryoblast → Megakaryocyte → Thrombocyte (platelets)

Question 2

Thrombopoiesis / megakaryoctyopiesis is stimulated by

Answer 2

Thrombopoeitin

Question 3

Between Megakaryoblast and megakaryocte

Answer 3

promegakarycote

Question 4

As megakaryocytic cell matures…

Answer 4

Cell volume increases (different than any other cell line) - till fragmented

NC ratio decreases

Chromatin - condenses

Nucleoli - disappear

Undergoes endomitosis → nuclear material continuously doubles without dividing, resulting in polyploid nucleus

Question 5

Megakaryoblast

Answer 5

Cytoplasm: pseudopodia present (ONLY class with these ) + non granular

Question 6

Promegakaryocyte

Answer 6

Cytoplasm → pseudopodia + fine azurophilic granules

Question 7

Answer 7

promegakaryocyte

Question 8

Answer 8

Megakaryocyte (w/ platelets)

Question 9

Answer 9

megakaryocyte (w/o platelets)

Question 10

Megakaryocyte

size

Nucleus

Cytoplasm

NC

BM

Answer 10

size → 30-100 micro m

Nucleus → central and +2 lobules. blue/purple. granular, no nucleoli

Cytoplasm → pale/blue pink. Numerous azurophilic granules

NC → 1:1 - 1:2

BM

Question 11

PLTs breaking off

Answer 11

metamegakaryocyte

Question 12

Answer 12

platelet/thrombocyte

Question 13

Answer 13

thrombocyte / platelet

Question 14

Answer 14

thrombocyte/platelet

Question 15

thrombocyte/platelet

size

Nucleus

Cytoplasm

granulomere

Answer 15

size → 1-4 micro m

Nucleus → none

Cytoplasm → light blue. reddish-blue granules

granulomere → central portion / red granules

Question 16

hyalomere

Answer 16

pale portion/ the clearing area/ not refractive of a platelet/ thrombocyte

Question 17

Platelets form _______ _____ between each other in megakaryocyte

Answer 17

demarcation membranes

Question 18

30% of platelets sequestered in ___ as reserve

Answer 18

spleen

Question 19

aged or dead platelets are removed by ___ and ___; similar system as RBC

Answer 19

spleen and liver

Question 20

platelets are individual ___ ____ released into peripheral blood

Answer 20

cytoplasmic fragment

Question 21

platelets circulate

Answer 21

9-12 days

Question 22

platelets contain chemicals that function to:

Answer 22

1. maintain blood volume integrity
2. initiate homeostasis
3. promote coagulation - provide a template to grow clot on and initiating other clotting factors

Question 23

when vessel or tissue is damaged, the platelets

Answer 23

change shape, become clumpy and sticky (primary homeostasis)

Question 24

Answer 24

osteoclasts

(separated nuclei)

Question 25

Osteoclasts (macrophage in bone) size Nucleus Function NC BM

Answer 25

size: \>100 micro m Nucleus - **2-50 separated nuclei with visible nucleoli** Function → absorption of bone NC BM