Flashcards in Thyroid Disorders Deck (20):
What regulates the amount of thyroid hormone that reaches the fetus?
Thyroid hormone abnormalities negatively affect what aspects of growth/aging in children?
What are common symptoms (or patient complaints) associated with hypothyroidism?
2. dry/coarse skin
3. feeling cold
4. hair loss
7. wt gain (poor appetite)
What are common physical signs associated with hypothyroidism?
1. puffy face/hands/feet
2. diffuse alopecia
4. peripheral edema
5. carpal tunnel syndrome
6. serous cavity effusions
7. delayed tendon reflex relaxation
What are common symptoms (or patient complaints) associated with hyperthyroidism?
4. heat intolerance or sweating
6. wt loss with increased appetite
9. loss of libido
What are common physical signs associated with hyperthyroidism?
2. a-fib in elderly
5. warm/moist skin
6. muscle weakness, prox myopathy
7. lid retraction
What labs are used to assess thyroid function? (Which of these is most useful?)
T4 (total + free)
T3 (total + free)
What are possible causes of inappropriate TSH labs, which point to hyperthyroidism?
TSH secreting pituitary adenoma
isolated pituitary resistance to thyroid hormone
What are possible causes of inappropriate TSH labs, which point to euthyroid?
generalized resistance to thyroid hormone
What are possible causes of inappropriate TSH labs, which point to hypothyroidism?
Why don't you see changes in T4 quickly in response to therapy?
T4 has a long half life, 6.2 days
Why do you see changes in T3 quickly in response to therapy?
T3 has a short half-life, 1 day
What are endogenous causes of hyperthyroidism?
2. toxic multinodular goiter
3. toxic adenoma
4. activating mutation of TSH receptor or Gs(alpha)
5. strauma ovarii
7. secondary hyperthyroidism
What are the causes of primary hypothyroidism?
2. RIA trx for Graves
4.excessive iodine intake
5. iodine deficiency
6. inborne errors of TH synthesis
What drugs cause primary hypothyroidism?
How is thyroiditis classified?
4. Riedel's thyroiditis
Causes of thyroid enlargement:
--Diffuse nontoxic (simple) goiter
--Nontoxic multinodular goiter
--Toxic multinodular goiter
--Hyperfunctioning solitary nodule
How is thyroid cancer classified?
--Well differentiated (Papillary, Follicular)
--Medullary thyroid carcinoma
What are the risk factors for thyroid cancer?
--Hx of head/neck radiation
--M, < 20 or > 45 y/o
--New or enlarging neck mass
--Hoarse voice/vocal cord paralysis
--Family history of thyroid cancer or MEN 2