Topic 7 Last Flashcards
(48 cards)
Geneotype vs Phenotype
- Genotype is the genetic constitution of an organism
- Phenotype is the expression of this genetic constitution and its interaction with the environment.
What are alleles?
- Different forms of the same gene
Dominant, recessive, co-dominant
- Dominant allele needs one allele present to be expressed in the phenotype
- Recessive alleles need 2 copies present to appear in the phenotype
- Co-dominant alleles are alleles that are both expressed in the phenotype.
What is monohybrid inheritance
- Inheritance of one single character, controlled by a single gene.
What is dihybrid inheritance?
- Inheritance of 2 characteristics, controlled by 2 genes
- Involves 2 genes on 2 different chromosomes
What is codominance
- Both alleles will be expressed in the phenotype
What are the 3 possible phenotypes in codominance
1) Heterozygous of both alleles
2) Homozygous of one allele
3) Homozygous of another allele
What are multiple alleles?
- Where some genes have more than 2 alleles, for example bloody type, where type a and b are codominant over allele iO.
What is sex-linkage and what impact do Male’s XY have?
- A gene that is found on a sex chromosome is said to be ‘sex-linked’
- Most genes on sex chromosomes are carried by the X chromosome so males are much more likely to show recessive phenotypes for sex linked genes as they only have one X chromsome .
Why are females said to be carriers of recessive genes?
- Their dominant allele on their X chromsome may cancel out the recessive allele on the Y chromosome.
What is autosomal linkage?
- Autosomal Genes that aren’t found on sex chromosomes.
- Genes found on the same autosome are said to be ‘linked’
- They will stay on the same chromosome during independent segregation in meiosis 1 and offspring will inherit these alleles together.
- The more closely two genes are together on the same chromosome, the less liekly they’ll be split by crossing over.
Why is there a 3:1 ratio during autosomal linkage?
- Because the 2 linked alleles are inherited together.
What is epistasis?
- The effect of one gene upon another.
- 2 genes interact, so that one may be masked (prevented from being expressed) by another.
Why does epistasis make it difficult for genetic investigations?
- If the effect of one locus is altered by the effect at another locus, power to detect the first locus is reduced.
What is chi-squared used for?
- Used to compare the goodness of fit of observed phenotypic ratios with expected ratios
- Can use to see if there is a dihybrid cross with linkage or no linkage
Why is it rare to get exactly the expected phenotypic ratios?
- Random fertilisation of gametes
- Epistasis
- Small sample size
What is a population?
- A group of organisms of the same species occupying a particular space at a particular time that can interbreed.
What is the gene pool?
- The complete range of alleles present in a population.
What is the allele frequency?
- How often an allele occurs in a population.
What is the prediction of Hardy Weinberg?
- Mathematical model which predicts that allele frequencies will not change from generation to generation.
Equations of Hardy Weinberg?
P+Q=1 (allele frequencies)
p^2+2pq+q^2=1 (frequency of individuals)
P - frequency of dominant alleles
Q - frequency of recessive alleles
2pq - Homozygous
What is Hardy Weinberg used for?
- To see whether the frequency of alleles is changing (if there is a selection pressure)
- We know this as we can measure the frequency of individuals in a population
Assumptions by the Hardy Weinberg
1) No natural selection meaning equal chance of survival and reproduction
2) Assumes there is no gene flow, introducing new genes or altering existing genes.
3) Assumes the population is large and isn’t affected by genetic drift
4) Assumes that there are no mutations as allele frequencies don’t get altered.
What is disruptive selection?
- When two extreme genotypes at both ends of the range are the most common and likely to survive and reproduce.