Topnotch - Genesis

Question 1

Components of nucleotide

Answer 1

phosphate group
nitrogenous base
sugar

Question 2

Drug Induced Lupus

Answer 2

methyldopa
sulfa drugs
hydralazine
isoniazid
procainamide
phenytoin
etanercept

Question 3

Histones are rich in

Answer 3

lysine

leucine

Question 4

Rate limiting enzyme of de novo purine synthesis

Answer 4

glutamine PRPP amidotransferase

Question 5

Can cause SCID

Answer 5

adenosine deaminase (ADA) deficieny

Question 6

Metabolizes Azathioprine and 6 MP

Answer 6

Xanthine oxidase

Question 7

Rate limiting enzyme in PYRIMIDINE synthesis

Answer 7

CPS II

Question 8

Orotic aciduria treatment

Answer 8

Uridine

Question 9

Lactose

Answer 9

galactose + glucose

Question 10

Sucrose

Answer 10

fructose + glucose

Question 11

Sites of Na dependent entry of glucose

Answer 11

intestinal epithelium

renal tubules

Question 12

GLUT 1

Answer 12

brain

RBC

Question 13

GLUT 4

Answer 13

fat tissue

skeletal muscle

Question 14

Rate limiting enzyme GLYCOLYSIS

Answer 14

PFK1

Question 15

PFK 1 (-)

Answer 15

citrate

ATP

Question 16

PFK1 inducers

Answer 16

AMP

fructose 2,6 bisphophate

Question 17

Activates pyruvate kinase

Answer 17

fructose 1,6 bisphosphate

Question 18

(-) pyruvate kinase

Answer 18

ATP

alanine

Question 19

Form of cholesterol in chylomicrons

Answer 19

cholesteryl ester

Question 20

Cells that synthesizes chylomicrons

Answer 20

enterocytes

Question 21

Packaged inside chylomicrons

Answer 21

TGL
cholesteryl esters
vit ADEK

Question 22

Synthesize HMG-CoA

Answer 22

HMG-CoA synthase

Question 23

Enzyme in cholesterol synthesis inhibited by statin

Answer 23

HMG-CoA reductase

Question 24

Lipoproteins that deliver CHOLESTEROL and TGL to the body

Answer 24

VLDL

HDL

Question 25

Apoproteins on HDL

Answer 25

apo I apo C-II apo E

Question 26

Apoproteins on HDL that are donated to other lipoproteins

Answer 26

apo C-II | apo E

Question 27

LCAT function

Answer 27

esterifies cholesterol

Question 28

Apoproteins on VLDL

Answer 28

apo B100 apo CII apo E

Question 29

Remove TGL from VLDL

Answer 29

lipoprotein lipase | CETP

Question 30

Remove TGL from IDL

Answer 30

hepatic lipase | CETP

Question 31

HDL is a repository for which apolipoprotein

Answer 31

apo C-II | apo E

Question 32

Must be present for GKRP to inactivate glucokinase

Answer 32

F6P

Question 33

Enzyme that commits glucose to glycolysis

Answer 33

PFK1

Question 34

Inhibited by alanine in glycolysis

Answer 34

pyruvate kinase

Question 35

Most affected by pyruvate kinase deficiency

Answer 35

RBC

Question 36

Intermediate in the conversion of pyruvate to PEP in gluconeogenesis

Answer 36

OAA

Question 37

Converts pyruvate to OAA in gluconeogenesis

Answer 37

pyruvate carboxylase

Question 38

Converts OAA to PEP in gluconeogenesis

Answer 38

PEP carboxykinase

Question 39

Cofactor of pyruvate carboxylase

Answer 39

ATP Biotin CO2

Question 40

Cofactor required by PEP carboxykinase

Answer 40

GTP

Question 41

Biotin is cofactor for which enzymes

Answer 41

pyruvate carboxylase acetyl CoA carboxylase propionyl CoA carboxylase

Question 42

Rate limiting for gluconeogenesis

Answer 42

FBPase I

Question 43

Location of glucose 6 phosphatase

Answer 43

liver | kidney

Question 44

Organelle where glucose 6 phosphatase is active

Answer 44

ER

Question 45

Glycogen is most abundant

Answer 45

muscle | liver

Question 46

Lysosomal enzyme that converts glycogen to glucose

Answer 46

alpha 1,4 glucosidase

Question 47

Produced by glycogen phosphorylase

Answer 47

G1P

Question 48

Enzymes that glucagon phosphorylates

Answer 48

glycogen phosphorylase | glycogen synthase

Question 49

Von Gierke Treatment

Answer 49

frequent cornstarch ingestion b/w meals | avoidance of fructose and galactose

Question 50

MC cause of death in Pompe disease

Answer 50

HF (hypertrophic cardiomyopathy)

Question 51

Glycogen storage disease presents in adolescence or early adulthood myoglobinuria AFTER exercise

Answer 51

Mc Ardle disease

Question 52

Genetic inheritance of Glycogen storage diseases I - IV

Answer 52

autosomal recessive

Question 53

Accumulation of limit dextrins in cytosol

Answer 53

Cori disease - debranching enzyme deficiency

Question 54

Converts G6P to phosphogluconolactone

Answer 54

G6PD

Question 55

Storage molecule produced through the action of G6PD

Answer 55

NADPH

Question 56

Produced at the end of the oxidative portion of HMP shunt

Answer 56

ribulose 5 phosphate 2 NADPH CO2

Question 57

G6PD deficiency

Answer 57

x-linked recessive

Question 58

PBS finding in G6PD deficiency

Answer 58

Heinz bodies (bite cells)

Question 59

Anti malarial that can precipitate G6PD deficiency

Answer 59

Primaquine | Quinidine

Question 60

Location of HMP shunt

Answer 60

cytosol

Question 61

Enzyme in HMP shunt that requires thiamine as cofactor

Answer 61

transketolase

Question 62

Enzyme in respiratory burst that requires NADPH as cofactor

Answer 62

NADPH oxidase

Question 63

Rate limiting enzyme in the oxidative part of HMP shunt

Answer 63

G6PD

Question 64

Carbohydrates taken up into the enterocytes by SGLT1 transporter

Answer 64

glucose | galactose

Question 65

Clinical presentation of essential fructosuria

Answer 65

fructose in blood and urine

Question 66

Cofactors for pyruvate dehydrogenase complex

Answer 66

``` thiamine lipoic acid CoA FAD NAD ```

Question 67

Symptoms of Dry Beriberi

Answer 67

polyneuropathy | symmetrical muscle wasting

Question 68

Symptoms of Wet Beriberi

Answer 68

tachycardia high output HF edema

Question 69

Poison that (-) lipoic acid

Answer 69

arsenic

Question 70

PDH complex deficiency

Answer 70

x-linked recessive

Question 71

Purely ketogenic AA

Answer 71

leucine | lysine

Question 72

Disorders of thiamine deficiency

Answer 72

Beriberi | Wernicke-Korsakoff syndrome