Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Hippos > Tox > Flashcards

Tox Flashcards

(61 cards)

Start Studying
1
Q

What is the MOA of NAC in tylenol OD?

A

Restores glutathione

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the first lab test that changes with tylenol overdose?

A

INR, not LFTs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What happens with INR when giving NAC?

A

Increases slightly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the active medication in Jimson weed?

A

Atropine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the treatment for anticholinergic overdoses?

A

Benzos
GSC
Foley for urinary retention

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the major risk of giving physostigmine in the treatment of anticholinergic poisoning?

A

Increased risk for seizures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the MOA of botulism?

A

Prevents the release of acetylcholine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Who do you call to get anti botulinum toxin?

A

CDC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What other property does propranolol have that make it different from other beta blockers in overdose?

A

Na channel blockade

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Why isn’t glucagon effective in the treatment of CCB overdoses?

A

Glucagon works by working around the cAMP beta agonist, but if there is no Ca to go around, it will not work

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Why isn’t pacing as effective in the treatment of beta blocker overdose?

A

Do not have the Ca for ionotropy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which has hyper and which has hypoglycemia: beta blockers vs CCBs?

A

Beta blockers have hypoglycemia whereas CCBs have hyperglycemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Foxglove causes what intoxication?

A

Digitalis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the only arrhythmia that you cannot have with Digitalis?

A

Rapidly conducted SVT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Does dig cause hyper or hypokalemia? Which causes a more potent effect with dig?

A

causes hyperkalemia, but more potent effect with hypokalemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the major issue with transvenous pacing with digitalis intoxication?

A

Since digitalis causes an irritable myocardium, there is a risk of a fatal arrythmia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is the role of tachycardia with QTc prolongation?

A

Protective, since it shortens the QTc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is the role of phenytoin in the treatment of TCA overdose?

A

Do not give, ineffective

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is the biggest tox killer?

A

CO

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

How can methylene chloride cause CO poisoning? What is it used for?

A

Wood stripping agent that gets converted into CO in the body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is the clinical presentation of CO poisoning?

A

Flu like symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Who gets hyperbaric oxygen therapy for CO poisoning?

A

Pregnant

Cardiac or neuro s/sx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What is the MOA of imidazolines, and what is the common suffix?

A

alpha agonists (oxymetaoline, tetrahydrolozine)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Opioid toxidrome with bradycardia, hypotension, and not responsive to narcan = ?

A

Clonidine overdose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
What is the toxin that smells like bitter almonds?
Cyanide
26
What is the toxin that smells like rotten eggs?
Hydrogen sulfide
27
Blackened coins in a tox vitim = ?
Hydrogen sulfide
28
What is the MOA of cyanide?
Inhibit oxidative phosphorylation, causing severe lactic acidosis
29
What is the MOA of hydrogen sulfide?
Inhibit oxidative phosphorylation, causing severe lactic acidosis
30
Arterialization of venous gas = which toxin?
Cyanide or hydrogen sulfide
31
How does a victim of cyanide poisoning present?
Sudden syncope/seizure
32
What is the treatment for cyanide poisoning? MOA? (2)
- Amyl nitrite induces methemoglobinemia | - Hydroxocobalamin, Vit B12 precursor
33
How do inhalants (hydrocarbons) cause intoxication? Treatment?
Myocardial sensitization | Beta blockers
34
What is the major cause of death and damage with hydrocarbon (like gasoline) ingestion?
Aspiration, since will damage surfactant in lungs and cause ARDS. Otherwise not typically dangerous
35
What is the presentation of hydrofluoric acid contamination?
Pain out of proportion to exam
36
What is the treatment for hydrofluoric acid contamination/ingestion?
Calcium
37
What is the toxic and lethal dose of Fe?
20 mg/kg toxic | 60 mg/kg lethal
38
What is the active form of Fe in tablets that is toxic?
The elemental form
39
What is the treatment for Fe intoxication? (2, early, definitive)
-Whole bowel irrigation if early | Deferoxamine
40
Why does isoniazid cause seizures? Treatment?
- Inhibits production of GABA | - Treat with B6 (pyridoxine)
41
How safe if pyridoxine in the treatment of isoniazid overdose?
Very. Extremely unlikely to overdose on B6 in the acute setting
42
What are the s/sx of Li intoxication?
Tremors, coma, seizures. Rarely cardiac arrhythmias
43
What is the treatment for Li poisoning?
IVFs, dialyze.
44
Why is there a rebound effect of Li levels after dialysis?
Large volume of distribution
45
What is metal fume fever?
Welder who gets sick monday morning and improves throughout the week
46
What is the underlying MOA of methemoglobinemia?
Fe2+ to Fe3+
47
What is the treatment for methemoglobinemia
Methylene blue
48
What are the causes of methemoglobinemia?
Nitrites, Aniline dyes Dapsone
49
People with what genetic disorder cannot get methylene blue for methemoglobinemia?
G6PD deficiency
50
What is the six hour rule with mushrooms?
If sick within 6 hours, will be fine.
51
Gyrometra species of mushrooms cause what intoxication?
Like isoniazid tox--seizures that are treated with B6
52
How do you titrate atropine in a organophosphate poisoning?
Until secretions dry
53
True or false: tachycardia is a contraindication to the use of atropine in the treatment of organophosphate poisoning?
False--give even if very tachy
54
What is the treatment for ASA poisoning?
WBI | Alkalinize the urine
55
What are the indications for dialysis with ASA tox?
- Pulmonary or cerebral edema - Renal failure - Severe acidemia - Level over 60 if chronic or 100 if acute
56
What is the role of activated charcoal in the treatment if ASA?
Can be used if early
57
What is the presentation of Strychnine intoxication? Why?
Opisthoclonus | Tox like tetanus
58
What agent may help with sulfonylureas overdose?
Octreotide
59
What is the presentation of theophylline OD?
- Refractory Seizure since adenosine is blocked in brain | - Refractory V-tach
60
Why do beta blockers work in the treatment of theophylline toxicity?
Theophylline is a beta agonist
61
True or false: theophylline is amenable to dialysis
True

Hippos (23 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions