1
Q
What is a toxidrome?
A
Clinical patterns of signs & symptoms of poisioning.
2
Q
What is the pathophysiology of paracetamol poisioning?
A
Paraectamol metabolised in liver mainly by conjugation with glucuronide & sulphate, but when they are saturated, also by CYP450 which produces toxic metabolite. Toxic metabolite detoxified in conjugation with hepatic glutahione. When glutahione depleted, toxic medabolite binds to hepatocyte protiens & damages.
3
Q
How does paracetamol poisoning treatment work?
A
Acetylcysteine increases glutahione to conjugate with toxic metabolite.
4
Q
Glucuronide & sulphate metabolise what?
A
Paracetamol. When saturated CYP450 metabolises instead producing toxic metabolite.
