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Flashcards in Transfusions Deck (11):

What are four differences between IgG and IgM?

(1) IgG warm agglutination, IgM cold agglutination
(2) IgG does not lyse RBCs, IgM binds complement and lyses RBCs
(3) IgG crosses placenta, IgM does not cross placenta
(4) IgG binds protein-rich antigens, IgM binds carbohydrate-rich antigens


What are two differences between type 1 and type 2 blood group chains?

Type 1 has a β1→3 linkage and chains are secreted
Type 2 has a β1→4 linkage and chains are membrane-associated


What is the structure of antigens in the O, A, and B blood groups?

O - H antigen
A - H antigen + Gal-NAc
B - H antigen + Gal


What is the Bombay phenotype and what are its consequences?

Oh genotype, no H antigen on RBCs
Appear as type O but cannot receive type O blood donations; donors must also have Bombay phenotype


Which populations have i and I antigens?

i = children
I = adults


What is anti-I antibody associated with?

Cold hemagglutinin disease (CHAD) and Mycoplasma pneumoniae


What is anti-i antibody associated with?

Infectious mononucleosis


How can hydrops fetalis due to Rh- mother and Rh+ fetus be prevented?

Give mother anti-D Ab (Rhogam) at 28 weeks and delivery, which will bind Rh+ fetal blood cells and mark them for destruction, preventing maternal production of anti-D alloantibody


What microbes bind Leb antigen?

H. pylori and Norwalk virus


What is anti-P1 antibody associated with?

Paroxysmal cold hemoglobinuria (aka Donath-Landsteiner syndrome) - biphasic hemolysin due to binding of antibody in cold temperatures and hemolysis in warm temperatures
Seen in bird handlers


What do anti-Kell antibodies cause?

Anti-Kell (anti-K) antibodies cause hemolysis and bone marrow suppression