Transmitters and Receptors Flashcards Preview

Neuro Block > Transmitters and Receptors > Flashcards

Flashcards in Transmitters and Receptors Deck (19):
1

How do drugs in the CNS interfere with chemical neurotransmission?

by affecting neurotransmitter: Synthesis, storage, release, inactivation (reuptake or metabolism) or receptor binding

2

What effect do Cocaine and Amphetamines have on the CNS? how do they do this?

increase NA in the synaptic cleft. Cocaine blocks reuptake of NA, whilst Amphetamines act directly on the storage vesicles and displaces NA

3

What are the main treatment options for epilepsy?

Reduce Excitatory input (Phenytoin) or Enhance inhibitory Input (Benzodiazepines)

4

How does Phenytoin work?

binds and inhibits intracellular portion of Na channels (channel has to be open to work) - blocking Na entry thereby decreasing excitatory fibre activity (ie less glutamate release?)

5

How do Benzodiazepines work?

Bind to the GABA A receptor at an allosteric site and enhances receptor infinity for GABA - which increases the frequency of the chloride channel opening. Increases the potency of GABA

6

What neurotransmitters are targeted for Anxiety?

Serotonin, NA, Neuropeptide Y

7

What neurotransmitters are targeted for Sedation?

Histamine

8

What neurotransmitters are targeted in the treatment of anxiety & sedation?

GABA, Serotonin

9

What are benzodiazepines used for?

Epilepsy, Anxiety, Sleep disorders, Premedication, Acute alcohol withdrawal

10

What drugs are used in the treatment of anxiety?

Benzodiazepines
Beta-adrenoceptor antagonists
Buspirone - partial agonist of 5HT1a receptor
Zopiclone - bind GABA A receptor
Zolpidem - bind GABA A receptor
Barbiturates (in the past)

11

How do barbiturates work? what is their effect?

general depressants, bind GABA A receptor and increase the duration of Cl channel opening. Increases the efficacy of GABA

12

Which receptor do Benzodiazepines bind?

GABA A receptor

13

What kind of receptor is the GABA A receptor?

ligand-gated ion channel

14

What is the ligand and what is the ion involved in the GABA A receptor?

ligand = GABA, Ion = Cl

15

Why are benzodiazepines considered safer than barbiturates?

benzodiazepines are allosteric modulators so have a ceiling effect and do not increase the maximal response -> safer in overdose, whereas barbiturates act directly on the channel and increase the maximal response & no ceiling effect so in overdose can lead to coma and death

16

What are some short acting benzodiazepines?

Oxazepam, Temazepam (6-12hrs)

17

What are some medium to long acting benzodiazepines?

Clonazepam, Diazepam

18

What kind of receptor is the GABA B receptor?

GPCRs

19

Which non-diazepine binds the same site of the GABA A receptor?

Zolpidem