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Flashcards in CNS infections Deck (17):
1

What are the most common viral causes of meningitis?

Enteroviruses, Coxsackie, Echo viruses

2

What are the most common bacterial causes of meningitis in adults and children?

H. influenza type B, Neisseria meningitidis, S. pneumoniae

3

What 3 bacteria are most common causes of meningitis in children < 3months?

Group B streptococci
Listeria
E coli

4

What are the clinical signs of meningitis in adults?

fever, headache, vomitting,
stiff neck, altered mental state (but usually conscious- differs to encephalitis), photophobia, rash, seizures

5

How do babies present with meningitis

more non-specific: irritable, stop feeding, fever, nausia, bulging fontanelle, altered mental state

6

What are the characteristics of normal CSF?

Clear appearance
WBCS 2.5mmol/L
Pressure <0.4g/L
NO RBCs, NO bacteria

7

How is meningitis treated?

3rd gen cephalosporins for adults + penicillin + ? for infants, and steroids (

8

What fungi and Protozoa can cause meningitis?

Cryptococcus (fungus) and amoeba

9

Why is CSF often cultured in serum broth?

Resuscitation medium -> rich broth that will support growth of small number of bacteria that may have survived initial empirical treatment

10

What empirical therapy is used in cases of suspected bacterial meningitis?

Cefotaxime (3rd gen cephalosporin)
Benzyl penicillin

11

What clinical signs are indicative of N. Meningititis? Meningococcal meningitis?

Fine petechial rash (small bruises)

12

What are the features of the bacteria N meningititis?

Gram neg diplococci

13

Why is meningitis caused by strep pneumoniae particularly important to identify?

Increasing resistance to beta lactam a -> may not respond to therapies -> add vancomycin to treatment
Also has highest rates of mortality and sequalae

14

What are the group B strep? In what group of individuals do they commonly cause meningitis?

Gram pos cocci in chains,Beta haemolytic
Commonly grow in gut and vaginal tract and can be contracted by newborns during birthing

15

What percentage of women carry group b strep as part of their flora?

25-30% of women

16

What methods can be used to reduce the incidence of newborn meningitis?

Screen mothers for Group B strep, if found to be carrying the bacteria give them IV penicillin 4 hours before birth. Can also treat baby with IV penicillin.

17

What is the prognosis of viral meningitis? Is it usually milder or more severe than bacteria?

Milder presentation, disease is usually self limiting and prognosis is good