Treatment

Question 1

What is the treatment for steroid and alcohol-related hepatitis?

Answer 1

• Offer corticosteroid treatment
• Only after treating any active infection, GI bleeding or renal impairment
• Shown to improve survival short-term (1 month)

Question 2

What is the treatment of neonatal jaundice?

Answer 2

• Fluid and caloric intake will prevent worsening
• Unconjugated hyperbilirubinaemia may be treated with phototherapy or exchange transfusion
• Conjugated hyperbilirubinaemia due to obstruction - treat underlying condition

Question 3

What is the management for primary biliary cholangitis?

Answer 3

• first-line: ursodeoxycholic acid
  slows disease progression and improves symptoms
• pruritus: cholestyramine
• fat-soluble vitamin supplementation
• liver transplantation
  e.g. if bilirubin > 100 (PBC is a major indication)
  recurrence in graft can occur but is not usually a problem