Tumor Suppressor Genes 2 Flashcards by Peter Chamberlin

Q

p53

A

Most cancer, Li-Fraumeni Syndrome

Chromosome 17

TF for p21 which inhibits G1 => S phase

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Q

PTEN

A

Breast, prostate, endometrial cancer

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Q

Rb

A

Retinoblastoma, osteosarcoma

Inhibits E2F; blocks G1 = S phase

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Q

TSC1

TSC2

A

Tuberous sclerosis

TSC1: Hamartin protein
TSC2: Tuberin protein

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Q

VHL

A

von Hippel-Lindau disease

Inhibits hypoxia inducible factor 1a

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Q

WT1

WT2

A

Wilms Tumor (nephroblastoma)

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