Unit 2: Ch 26 Nutrition (v2) Flashcards
(73 cards)
1
Q
Amino acid conversion processes
A
- Deamination: removal of an amino group (−NH2)
- Amination: addition of an amino group (−NH2)
- Transamination: transfer of amino group (−NH2) from one molecule to another
2
Q
Arcuate nucleus of hypothalamus (appetite)
- Description
A
- All five chemical signals of short and long-term appetite regulators present
-
2 neural networks involved in hunger
-
Neuropeptide Y (NPY); appetite stimulant
- stimulated by gherlin
- inhibited by insulin, PYY, and leptin
-
Melanocortin; appetite inhibitor
- stimulated by leptin
- inhibited by endocannabinoids (appetite stimulants)
-
Neuropeptide Y (NPY); appetite stimulant
-
2 neural networks involved in hunger
3
Q
Vitamin B
- Soluability
- Function
A
- Water soluable
- Function as coenzymes
4
Q
Mechanisms for high body temperature
- Describe
A
- When heat-loss center senses that the blood temperature is too high it activates heat-losing mechanism
-
Cutaneous vasodilation
- Increases blood flow close to the body’s surface and promotes heat loss
- Triggers sweating which inhibits heat-promoting center
-
Cutaneous vasodilation
5
Q
Mechanisms for low body temperature
- Describe
A
- When heat-promoting center senses that the blood temperature is too low it activates mechanisms to conserve heat or generate more
-
Cutaneous vasoconstriction
- By way of the sympathetic nervous system warm blood is retained deeper in the body and less heat is lost through the skin
-
Shivering thermogenesis
- involves a spinal reflex that causes alternating contractions of antagonistic muscle pairs
- every muscle contraction releases heat from ATP consumption
- can increase the body’s heat production up to fourfold
- involves a spinal reflex that causes alternating contractions of antagonistic muscle pairs
-
Non-shivering thermogenesis: long-term mechanism for generating heat
- sympathetic nervous system and thyroid hormone increase metabolic rate
- More nutrients burned as fuel, increased heat production, and we consume more calories
- Behavioral thermoregulation: behaviors that raise or lower the body’s heat gains and losses—adding or removing clothing
-
Cutaneous vasoconstriction
6
Q
Body mass index (BMI)
A
- Indication of being overweight or obese
- BMI = W/H2 (W = weight in kg; H = height in meters)
- 20 > 25 = optimal
- Over 27 = overweight
- Above 30 = obese
- BMI = W/H2 (W = weight in kg; H = height in meters)
7
Q
Sources of carbohydrate forms
- List & describe
A
- Nearly all dietary carbohydrates come from plants
- Fructose - fruits and corn syrup
- Lactose - cow’s milk
- Maltose - cereal grains
- Sucrose - sugarcane and sugar beets
8
Q
Carbohydrate forms
- List & describe
A
-
Disaccharides
- sucrose, maltose, lactose
-
Monosaccharides
- glucose, galactose, fructose
- arise from digestion of starch and disaccharides
- SI and liver convert galactose and fructose to glucose
- outside hepatic portal system, only blood sugar is glucose
- glucose, galactose, fructose
-
Polysaccharides (complex carbohydrates)
- starch, glycogen, and cellulose
9
Q
Glucose catabolism
- Describe
- Formula
A
- All oxidative carbohydrate consumption is glucose catabolism
- C<u>6</u>H<u>12</u>O<u>6</u> + 6 O<u>2</u> ⇢ 6 CO<u>2</u> + 6 H<u>2</u>O
- transfers energy from glucose to ATP
10
Q
Carbohydrates
- General description
A
- Fuel source; burned as fuel within hours of absorption
- Oxidized source of chemical energy
- Most cells meet energy needs by a combination of carbohydrates and fats
- Neurons and erythrocytes depend solely on carbohydrates
- Deficiency can lead to hypoglycemia
11
Q
Blood glucose concentration
- Interplay of ___ and ___
- Regulate’s balance between ___ and ___
A
- Blood glucose concentration is carefully regulated
- Interplay of insulin and glucagon
- Regulate balance between glycogen and free glucose
12
Q
Cholecystokinin (CCK)
- Description
- What does it stimulate?
- Secreted by?
A
- Short-term appetite regulator
- Stimulates
- secretion of bile and pancreatic enzymes
- brain and sensory fibers of the vagus nerve suppressing appetite
- Stimulates
- Secreted by enteroendocrine cells in duodenum and jejunum
13
Q
Cholesterol & exercise
A
- Vigorous exercise lowers blood cholesterol
- Sensitivity of right atrium to blood pressure is reduced
- Heart secretes less atrial natriuretic peptide and thus kidneys excrete less sodium and water
- Raises blood volume
- Dilution of blood lipoproteins causes adipocytes to produce more lipoprotein lipase
- Adipocytes consume more blood triglycerides
- VLDL particles shed some cholesterol which is picked up by HDL and removed by the liver
14
Q
T/F
Most of the body’s cholesterol is endogenous - internally synthesized rather than dietary?
A
True
- Body compensates for variation in intake
- High dietary intake lowers liver cholesterol production
- Low dietary intake raises liver production
- Lowering dietary cholesterol lowers level by no more than 5%
- Certain saturated fatty acids (SFAs) raise serum cholesterol level
- Moderate reduction in SFAs can lower blood cholesterol by 15% to 20%
15
Q
Chylomicrons
A
- Lipoprotein
- Produced in enterocytes from dietary lipids (fatty acids and cholesterol)
16
Q
Macronutrients & micronutrients
- Compare
A
- Macronutrients
- Must be consumed in relatively large quantities
- Water, carbohydrates, lipids, and proteins
- Micronutrients
- Only small quantities are required
- Vitamins and minerals
17
Q
Core body temperature
A
- Temperature of organs in cranial, thoracic, and abdominal cavities
- Rectal temperature is an estimate of core temperature
- Adult temperature varies normally from 99.0° to 99.7°F
18
Q
Define thermoregulation
A
The balance between heat production and loss
19
Q
Dietary fiber
- Describe
- List types
A
- All fibrous material of plant and animal origin that resists digestion
- Cellulose, pectin, gums, and lignins
- Fiber is important to diet (RDA is 30 g/day)
- Types
- water-soluable
- water-insoluable
20
Q
Essential nutrients
A
- Nutrients that cannot be synthesized in body
- Must be consumed in diet
21
Q
Hypothermia
A
- Core body temperature drops below 91°F
- Notes
- Metabolic rate drops so low that heat production cannot keep pace with heat loss
- Death from cardiac fibrillation may occur below 90°F
- Below 74°F is usually fatal
- Dangerous to give alcohol to someone in hypothermia, as it accelerates heat loss by dilating cutaneous vessels
22
Q
Impact of exposure to excessive heat
A
-
Heat cramps
- muscle spasms due to electrolyte imbalance from excessive sweating
- occur especially when a person begins to relax after strenuous exertion and heavy sweating
-
Heat exhaustion
- from severe water and electrolyte loss
- Hypotension, dizziness, vomiting, and sometimes fainting
-
Heat stroke (sunstroke)
- core body temperature is over 104°F
- brought about by prolonged heat wave with high humidity
- skin is hot and dry
- nervous system dysfunctions: delirium, convulsions, or coma
- tachycardia, hyperventilation, inflammation and multi-organ dysfunction, death
23
Q
Fat-soluble vitamins
- List & describe
A
- Incorporated into lipid micelles in the small intestine and absorbed with dietary lipids
-
Vitamin A
- Component of visual pigments
- Promotes proteoglycan synthesis and epithelial maintenance
- Antioxidant (ascorbic acid)
-
Vitamin D
- Promotes calcium absorption and bone mineralization
-
Vitamin E
- Antioxidant
-
Vitamin K
- Essential for prothrombin synthesis and blood clotting
-
Vitamin A
24
Q
Fever
A
- Normal protective mechanism that should be allowed to run its course if it is not excessively high
- Above 108° to 110°F can be very dangerous
- Elevates the metabolic rate
- Body generates heat faster than heat-losing mechanisms can disperse it
- Causes dangerous positive feedback loop
- Core temperatures of 111° to 113°F promote metabolic dysfunction, neurological damage, and death
25
Gastric peristalsis
* When **mild** **hunger contractions** begin after stomach is empty
* Increase in intensity over a period of hours
* Do not affect the amount of food consumed
26
Ghrelin
* Short-term appetite regulator
* Signal that begins a meal; produces sensation of hunger
* Secreted from parietal cells in **fundus of empty stomach**
* Stimulates the hypothalamus to secrete **growth hormone–releasing hormon & neuropeptide Y**
* Secretion ceases within an hour of eating
27
Glucose catabolism pathways
* List & describe
* **Aerobic respiration**
* Occurs in the presence of oxygen
* Completely oxidizes *pyruvic acid* to CO2 and H2O
* **Anaerobic fermentation**
* Occurs in the absence of oxygen
* Reduces *pyruvic acid* to lactic acid
* **Glycolysis**
* Glucose (6 C) split into two *pyruvic acid* molecules (3 C)
28
Gut-brain peptides
* Describe
Act as chemical signals from the gastrointestinal tract to the brain
29
HDL
* Function
* Where is it produced
* What does it produce
* A lipoprotein that removes excess cholesterol from the body
* Production begins in the _liver_; produces a _collapsed protein shell_
* High level of HDL is _beneficial_
30
Heat production & loss
* Most of the body’s heat comes from _exergonic chemical reactions_ (energy releasing such as joint friction, blood flow, and other movements)
* **At rest**
* most heat is generated by the _brain, heart, liver, and endocrine glands_
* Skeletal muscle contributes 20% - 30% of total resting heat
* **During vigorous exercise**
* muscles produce 30 - 40 times as much heat as the rest of the body
31
3 ways the body loses heat
* List & describe
1. **Conduction**: _Transfer of kinetic energy_ from molecule–molecule as they collide with one another
2. **Evaporation**: The change from a liquid to a gaseous state. _Forced convection_
3. **Radiation**: The emission of _infrared (IR) rays_ by moving molecules
32
Hypervitaminosis
Vitamin excess
33
Hypoglycemia
* Deficiency of blood glucose
* Causes nervous system disturbances such as weakness and dizziness
34
Hypoglycemia
* Describe
* Deficiency of blood glucose
* Causes nervous system disturbances such as weakness and dizziness
35
Hypothalamic thermostat
* The preoptic area of the hypothalamus functions as the _body’s thermostat_
* Monitors temperature of the blood
* Receives signals from peripheral thermoreceptors in the skin
* Sends appropriate signals to either the **heat-loss center:** a nucleus in the anterior hypothalamus or the **heat-promoting center** in a more posterior nucleus near the mammillary bodies of the brain
36
Insulin
* Describe
* Secreted by?
* Long-term appetite regulator
* Stimulates _glucose and amino acid uptake_
* Promotes _glycogen and fat synthesis_
* _Weaker_ effect on appetite than leptin
* Secreted by _pancreatic beta cells_
37
LDL
* Absorbed by receptor-mediated endocytosis by cells in need of cholesterol for membrane repair or steroid synthesis
* Digested by lysosomal enzymes to release the cholesterol for intracellular use
* Levels of LDL
* High LDL is a warning sign–Correlates with cholesterol deposition in arteries
* Elevated by saturated fat intake, cigarette smoking, coffee, and stress
38
Leptin
* Describe
* Secreted by?
* Long-term appetite regulator
* Informs brain on how much body fat we have
* Level proportionate to one’s own fat stores
* Obese people are more likely to have a receptor defect than hormone deficiency
* **Secreted by adipocytes** throughout the body
39
Lipid sources
* **Saturated fats**
* **Animal origin:** meat, egg yolks, dairy products
* **Unsaturated fats**
* Found in nuts, seeds, and most vegetable oils
* **Cholesterol**
* Found in egg yolks, cream, shellfish, organ meats, and other meats
* Does not occur in foods of plant origin
40
Lipid constitution in males/females
* Males = 15% body fat
* Females = 25% body fat
*Note: Well-nourished adult meets 80% to 90% of resting energy needs from fat*
41
Lipoprotein complexes
* Function
* Composition
* Transport lipids in _plasma_
* Coated with protein and phospholipids
* Coating allows lipid to be suspended in blood
* Also serves as a recognition marker for cells that absorb them
* Contain cholesterol and triglycerides
42
Long-term appetite regulators
* List
* Insulin
* Leptin
43
Megavitamins
* Doses 10 to 1,000 times the RDA
* Show no effect on performance
44
Metabolic rate
* Describe
* How is it measured
* The amount of energy liberated in the body in a given period of time (kcal/hr or kcal/day)
* **Calorimeter:** a closed chamber with water-filled walls that absorb the heat given off by the body
* Measured indirectly with a **spirometer** by measuring the amount of oxygen a person consumes
* Metabolic rate depends on physical activity, mental state, absorptive or postabsorptive status, thyroid hormone, and other hormones
45
Metabolic states & rate
* Describe
* List and describe states
* Metabolism changes from hour to hour
* Depending on how long since your last meal
* **Absorptive (fed) state**
* About 4 hours during and after a meal
* Nutrients are being absorbed
* Nutrients may be used immediately to meet energy and other needs
* **Postabsorptive (fasting) state**
* Prevails in the late morning, late afternoon, and overnight
* Stomach and intestines are empty
* Body’s energy needs are met from stored fuels
46
What is metabolism
The chemical change that lies at the foundation of form and function
47
Minerals & vitamins
* Minerals
* inorganic elements that plants extract from the soil or water and introduce into the food web
* Vitamins
* small dietary organic compounds that are necessary to metabolism
* Neither is used as fuel
* Both are essential to our ability to use other nutrients
48
Negative nitrogen balance
* Excretion exceeds ingestion of protein
* Body proteins being broken down for fuel; _muscle atrophy_
* Muscles and liver proteins are more easily broken down than others
* Carbohydrate and fat intake is insufficient to meet body’s energy needs
* _Glucocorticoids_ promote protein catabolism in states of stress
49
Neurotransmitters
* Describe
* What stimulates desire for what
* Stimulate desire for different types of food
* Endorphins: protein
* Galanin: fats
* Norepinephrine: carbohydrates
50
Normal body temperature variations
Varies about 1.8°F in a 24-hour cycle
Low in morning and high in late afternoon
51
Obesity
* Weight \> 20% above recommended norm for one’s age, sex, and height (US)
* 30% obese
* 35% overweight
52
Peptide YY (PYY)
* Short-term appetite regulator
* Signal that _ends a meal_
* Secreted by **enteroendocrine cells of ileum and colon**
53
Positive nitrogen balance
* Who experiences it?
* Occurs in
* athletes in resistance training
* children because they ingest more than they excrete retaining protein for tissue growth
* pregnant women
54
Protein amino acids
* Essential & inessential amino acids
* **8 essential amino acids** that cannot be synthesized by the body
* Isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine
* **12** **inessential amino acids** synthesized by the body if the diet does not supply them
* Cells do not store surplus amino acids for later use
* When a protein is synthesized, all amino acids must be present at once
* If one is missing, the protein cannot be synthesized
55
Protein types
* List & describe
* **Complete proteins**
* high-quality dietary proteins that provide all of the essential amino acids in the necessary proportions for human tissue growth, maintenance, and nitrogen balance
* **Incomplete proteins**
* lower quality because they lack one or more essential amino acids
56
Protein
* Body constitution
* Functions
* Components
* 12% - 15% of total body mass; 65% in skeletal muscle
* Functions
* Muscle contraction
* Motility of cilia and flagella
* Components
* _Cellular membranes_: receptors, pumps, ion channels, and cell-identity markers
* _Fibrous proteins:_ collagen, elastin, and keratin make up much of the structure of bone, cartilage, tendons, ligaments, skin, hair, and nails
57
Recommended daily allowances (RDA)
Safe estimate of daily intake that would meet the nutritional needs of most healthy people
58
Serum lipoproteins
* List & describe classifications
* Classified into 4 major categories by their _density_
* **Chylomicrons:** 75–1,200 nm in diameter
* **Very low–density lipoproteins (VLDLs):** 30–80 nm
* **Low-density lipoproteins (LDL):** 18–25 nm
* **High-density lipoproteins (HDL):** 5–12 nm
* Differences are in _composition and function_
59
Shell temperature
* Temperature closer to the surface (oral cavity and skin)
* Slightly lower that rectal temperature
* Adult varies normally from 97.9° to 98.6°F
* As high as 104°F during hard exercise
* Fluctuates in response to processes that maintain stable core temperature
60
Short-term regulators of appetite
* Describe
* List types
* Makes one feel hungry and begin eating and satisfied at end of a meal; effects last minutes to hours
* Types
1. Cholecystokinin (CCK)
2. Ghrelin
3. Peptide YY (PYY)
61
How is thermoregulation achieved?
Several negative feedback loops
62
Vitamin C
* Describe
* **Water soluable** antioxidant that scavenges free radicals and possibly reduces the risk of cancer
* Promotes hemoglobin synthesis, collagen synthesis, and sound connective tissue structure
* **Ascorbic acid**
63
Vitamin A
* Symptoms of excess & deficiency
* **Vitamin A excess**
* anorexia, nausea and vomiting
* headache and pain
* fragility in the bones
* hair loss
* enlarged liver and spleen
* birth defects
* **Vitamin A deficiency** (most common vitamin deficiency)
* night blindness
* dry skin and hair
* dry conjunctiva and cloudy cornea
* increased incidence of urinary, digestive, and respiratory infections
*Note: excess of vitamins B6, C, D & E can lead to _toxic hypervitaminosis_*
64
Vitamins from precursors (provitamins)
* Body synthesizes some vitamins from precursors called **provitamins**
* _Niacin_ from amino acid tryptophan
* _Vitamin A_ from carotene
* _Vitamin D_ from cholesterol
* _Vitamin K, pantothenic acid, biotin, and folic acid_ are produced by bacteria of the large intestine
65
Water-soluable vitamins
* Describe
* Vitamins C & B
* Absorbed with water in small intestine
* Quickly excreted by the kidneys, not stored, and seldom accumulate to excess
66
VLDL
* Describe
* Produced by _liver_ to transport lipids to adipose tissue for storage
* Develop when triglycerides are removed from adipose tissue
* Mostly comprised of cholesterol
67
Water-insoluble fiber
* List
* General description
* Cellulose, hemicellulose, lignin
* Description
* Absorbs water in intestines, softens stool, increases bulk 40% to 100%, stretches colon, and stimulates peristalsis thereby quickening passage of feces
* Excessive intake can interfere with absorption of elements such as iron, calcium, magnesium, phosphorus, and other trace elements
* No effect on cholesterol and LDL levels or colorectal cancer
68
What briefly satisfies appetite?
* Chewing
* Swallowing
* Stomach filling
*Note: Lasting satiation depends upon nutrients entering blood*
69
What do growth hormones & sex steroids promote?
Protein synthesis and positive nitrogen balance in childhood
70
What is a nutrient
Any ingested chemical used for growth, repair, or maintenance of the body
71
What is nutrition
* The starting point and the basis for all human form and function
* Source of **fuel** that provides the energy for all biological work
* Source of **raw materials** for replacement of worn-out biomolecules and cells
72
What is the chief source of nitrogen
Protein
73
Why is fat superior to carbs for energy storage?
* Fats
* contains almost no water, and is a **more compact energy storage substance**
* Fat is less oxidized than carbohydrates and **contains over twice as much energy** (9 kcal/g)
* Carbohydrates
* hydrophilic, absorb water, and expand and occupy more space in the tissues
* Contains less energy (4 kcal/g)