Unit 4 Study Guide Flashcards
v. What are the different types of grafts?
- Autograft
- Isograft (Identical twin or clone)
- Allograft (Same species)
- Xenograft (Different species)
- There are 3 types of cells that perform “nonphagocytic killing.” What are they?
a. Eosinophils
b. NK cells
c. Neutrophils
- What are pyrogens?
a. Trigger the hypothalamus to reset to a higher temperature
iii. What cells become sensitized in hypersensitivity
- Mast cells, basophils, eosinophils
- What is clonal deletion?
a. Deletion of self-reactive cells
- Endogenous antigens are presented on which type of MHC molecules?
a. Endogenous = Class I (cell-mediated)
i. What causes a type III hypersensitivity response?
- Antigens bound to antibodies (called immune complexes) avoid phagocytosis and stay in circulation until they ultimately get lodged in an organ or joint
- What are the 4 things that antimicrobial peptides do to fight pathogens?
a. Punch holes in cytoplasmic membranes
b. Interrupt internal signaling or enzymatic action
c. Chemotactic factors (recruit leukocytes to a site)
d. Form “nets” to ensnare invading bacteria
- When your internal thermostat gets reset at a higher temperature, what things does your body do to increase the temperature?
a. Nerve impulses trigger shivering
b. Higher metabolic rate
c. Inhibition of sweating
d. Vasoconstriction (keeps blood at the core)
- What is the end result of complement cascade activation?
a. Destruction of foreign cells
b. Note: Complement system is a set of serum proteins
- What are the different ways (2) in which the complement cascade can be activated? How do they differ?
a. Classical pathway – Occurs in conjunction with antibodies
b. Alternative pathway – Occurs independently of antibodies
c. C3 cleaved into two fragments (C3a and C3b)
i. What is an allergen?
- An antigen that stimulates an allergy
- What are the 3 ways in which normal flora act as part of the first line of defense?
a. Normal microbiota consumes all available nutrients
b. Changes the pH of regions of the body
c. Can generate antimicrobial compounds
- What is the main the surface glycoprotein on a Tc cell?
a. MHC class I
- What are interferons?
a. Inhibit viral infections nonspecifically
b. Cause malaise, muscle aches, chills, headache, and fever
- What is Graves’ disease?
a. Overstimulation of thyroid gland (excessive thyroid hormone)
iv. What does it mean if someone gets a positive TB result?
- They have been exposed to TB and have created antibodies
- What is the difference between a primary and an acquired immunodeficiency disease?
a. Primary is genetic
- What mechanisms do antibodies employ in order to destroy (or contribute to the destruction of) pathogens (6) and what is meant by each one?
a. Activation of complement
b. Inflammation
c. Neutralization – Antibodies bind to a critical portion of the pathogen so it can no longer cause harm
d. Opsonization – Antibodies act as opsonins, molecules that stimulate phagocytosis
e. Agglutination – Antibodies can bind to two epitopes at once, and bind many antigens together
f. Antibody-dependent cell-mediated cytotoxicity (ADCC) – Similar to opsonization, except NK cells are recruited to cause apoptosis
- What are the steps (3) during an inflammatory response?
a. Increased permeability and dilation
b. Migration (increase of phagocytes migrating via chemotaxis)
c. Tissue repair
- What is the mechanism of the interferon pathway?
a. Type I: Alpha and Beta
i. Nonspecific
ii. Macrophages, etc.
b. Type II: Gamma
i. Specific, works with adaptive immune system
ii. Produced much later
- What are the steps (6) of phagocytosis?
a. Chemotaxis – Phagocytes move towards or away from a chemical signal
b. Adherence – Coating of antimicrobial proteins = opsonization
c. Ingestion – The ingested microbe is now called a phagosome
d. Maturation – Fusion of lysosomes with phagosome = phagolysosome
e. Killing – Results in residual body
f. Elimination – Exocytosis – The phagolysosome becomes a residual body
- What pathogens do eosinophils usually attack?
a. Parasitic worms – attach and secrete toxins
v. How do the chemicals released during an allergic reaction affect physiology?
- Respiratory distress, rhinitis (runny nose), water eyes, inflammation, reddening of the skin
- What is a membrane attack complex (MAC)?
a. Forms circular holes in a pathogen’s membrane
- What is the lacrimal apparatus?
a. Lacrimal glands, ducts, canal, and duct to nasal passage
- What are goblet cells?
a. Produce a very sticky and thick mucous
- How does a cell-mediated immune response happen? What are the steps?
a. Antigen presentation
b. Th differentiation
c. Clonal expansion of Tc
d. Self-stimulation
ix. What are some treatments for mild hypersensitivities and for anaphylactic shock?
- Antihistamines
2. Epinephrine
iv. What are some of the parts of the body that are affected in a Lupus patient?
- Butterfly rash on the face