Vaccines Flashcards
(36 cards)
3 main side effects ***
infection - improper inactivation or person IC
inflammation and anaphylactic reaction - contaminates or preservatives
neurological and autoimmune - rare antigen cross reaction
what is thiomersol
mercury containing preservative
ethyl mercury which is easily eliminated by the body and prevents growth of the bacteria
has been targeted for causing autism
capsular polysaccharide effector mechanism
b cell response as t-independent manner
conjugation of polysaccharides to a protein carrier forms peptide antigens which generate what effector mechanism
recruit antigen specific CD4+ t helper cells in a t-dependent antibody response
protein antigens such as live attenuated vaccines generate what
CD8+ cytotoxic t cells
CD8+ effector mechanism
do not prevent infection but reduce/control INTRACELLULAR pathogens
either by direct killing through release of stuff or by indirect killing infected cells through cytokine release
CD4 cells effector mechanism
dont prevent infection but control/reduce extracellula and intracellular pathogens their homing and cytokine production
follicular t helper cells produce IL 21 providing…
B cell help
t helper 1 cells produce interferon gamma, tumor necrosis factor, and IL2 involved in …
protection against intracellular pathogens
t helper 2 cells produce IL4,5,13 and….
respond to extracellular pathogens
th17 cells produce IL17,22,26 and …
contribute to mucosal defence
ex.strep pneumo
what are human pattern recognition receptors
toll like receptors
recognize specific parts of an antigen and present it to the MHC
MHC class 1 = ___ pathogen
intracellular
MHC class 2 = ___ pathogen
extracellular
describe initation of a vaccine response
the pathogen associated pattern in the vaccine antigen attracts monocytes and dendritic cells and if the danger signal is loud enough it activates them
activation changes their surface receptor and they migrate back to the lymph node where B and T lymphocytes are activated
describe killed vaccine
heat or formaldehyde killed pathogen
ex. salk polio
describe live attenuated vaccine
selection of less pathogenic variants
ex. sabian polio, MMR
describe subunit vaccine
purified or genetically altered structural component of a pathogen
ex. hep B, influenza injection
describe conjugate vaccines
combo of multiple components to increase immunogenicity and memory
what are toxoids
toxins that are inactivated by mutation or chemcial treatment that are immunogenic but not pathogenic
ex.diptheria, tetanus
describe DNA vaccines
inject the gene that makes the protein or antigen
5 features of effective vaccines
safe: not cause illness or death
protective: protect against illness from exposure to a live pathogen
sustained protection: years
induces neutralizing antibody
induces protective t cells
what are neutralizing antibodies
prevent infection of cells that cant be replaced
3 types of adjuvants
oil in water emulsion
saponin
aluminum