Vaccines Flashcards

(36 cards)

1
Q

3 main side effects ***

A

infection - improper inactivation or person IC
inflammation and anaphylactic reaction - contaminates or preservatives
neurological and autoimmune - rare antigen cross reaction

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2
Q

what is thiomersol

A

mercury containing preservative
ethyl mercury which is easily eliminated by the body and prevents growth of the bacteria
has been targeted for causing autism

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3
Q

capsular polysaccharide effector mechanism

A

b cell response as t-independent manner

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4
Q

conjugation of polysaccharides to a protein carrier forms peptide antigens which generate what effector mechanism

A

recruit antigen specific CD4+ t helper cells in a t-dependent antibody response

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5
Q

protein antigens such as live attenuated vaccines generate what

A

CD8+ cytotoxic t cells

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6
Q

CD8+ effector mechanism

A

do not prevent infection but reduce/control INTRACELLULAR pathogens
either by direct killing through release of stuff or by indirect killing infected cells through cytokine release

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7
Q

CD4 cells effector mechanism

A

dont prevent infection but control/reduce extracellula and intracellular pathogens their homing and cytokine production

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8
Q

follicular t helper cells produce IL 21 providing…

A

B cell help

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9
Q

t helper 1 cells produce interferon gamma, tumor necrosis factor, and IL2 involved in …

A

protection against intracellular pathogens

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10
Q

t helper 2 cells produce IL4,5,13 and….

A

respond to extracellular pathogens

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11
Q

th17 cells produce IL17,22,26 and …

A

contribute to mucosal defence

ex.strep pneumo

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12
Q

what are human pattern recognition receptors

A

toll like receptors

recognize specific parts of an antigen and present it to the MHC

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13
Q

MHC class 1 = ___ pathogen

A

intracellular

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14
Q

MHC class 2 = ___ pathogen

A

extracellular

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15
Q

describe initation of a vaccine response

A

the pathogen associated pattern in the vaccine antigen attracts monocytes and dendritic cells and if the danger signal is loud enough it activates them
activation changes their surface receptor and they migrate back to the lymph node where B and T lymphocytes are activated

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16
Q

describe killed vaccine

A

heat or formaldehyde killed pathogen

ex. salk polio

17
Q

describe live attenuated vaccine

A

selection of less pathogenic variants

ex. sabian polio, MMR

18
Q

describe subunit vaccine

A

purified or genetically altered structural component of a pathogen
ex. hep B, influenza injection

19
Q

describe conjugate vaccines

A

combo of multiple components to increase immunogenicity and memory

20
Q

what are toxoids

A

toxins that are inactivated by mutation or chemcial treatment that are immunogenic but not pathogenic
ex.diptheria, tetanus

21
Q

describe DNA vaccines

A

inject the gene that makes the protein or antigen

22
Q

5 features of effective vaccines

A

safe: not cause illness or death
protective: protect against illness from exposure to a live pathogen
sustained protection: years
induces neutralizing antibody
induces protective t cells

23
Q

what are neutralizing antibodies

A

prevent infection of cells that cant be replaced

24
Q

3 types of adjuvants

A

oil in water emulsion
saponin
aluminum

25
3 main jobs of adjuvants
increase uptake by macropahges delay release of antigen induction of costimulators in macrophages
26
complete freuends adjuvant
oil in water with dead mycobacteria | does all 3 things
27
freunds adjuvant with MDP
oil in water with muramyl dipeptide and constituent of mycobacteria does all 3 things
28
incomplete freunds adjuvant
oil in water emulsion that enhances macrophage uptake and delays antigen release
29
immune stimulatory cmoplexes
matrix of saponin containing viral proteins delivers the antigen to the cytosol allows induction of cytotoxic t cells
30
formation of inactived or killed vaccines
bacteria etc grown in culture then killed by heat or formaldehye
31
live/attenuated vaccine formation
attenuated through passage of foreign host such as tissue culture, live animals, or embryonated eggs 1. isolate the virus in human cell 2. infectnon human cell 3. virus mutates to survive in new host 4. virus doesnt grow in human cells
32
conjugate vaccine formation
covalently attach a weak antigen (polysaccharide) to a strong antigen(protein) to elicit a stronger immunologic response
33
how is a conjugate bettwe than free polysaccharide
longer duration of antibody response can elicit memory and affinity maturation response in young infants
34
what are follicular t helper cells
unique t helper cells with high antigen binding potential | quantity and quality greatly affected by adjuvants
35
generation of a dna vaccination
used recombinat DNA technology to introduce a gene of an antigen into an expression vector then put that into a human or cell
36
what types of pathogens can be used in dna vaccinations
pathogens that mutate freely | such as influenza