1
Q
class of vancomycin
A
glycopeptides
2
Q
how does vancomycin inhibit cell wall synthesis
A
bacteriocidal. binds D-alanyl D-alanine oligopeptides
3
Q
why are b-lactamases ineffective against vancomycin
A
vancomycin doesn’t bind to PBPs
4
Q
activity of vancomycin
A
- staph
- strep
- enterococcus
- MRSA
5
Q
indications of vancomycin
A
- MRSA
- c.diff colitis
- endocarditis
6
Q
SEs vancomycin
A
- nephrotoxicity
- ototoxicity
- blood disorders
- severe hypotension
- Drug Reaction with Eosinophilia & Systemic Symptoms (DRESS)
7
Q
why is serum monitoring necessary in vancomycin
A
90% excretion via glomerular filtration
8
Q
IV & oral vancomycin excretion
A
- IV –> urine
- oral –> faeces
Y3 Antibiotics
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