VI-Pancreas

Question 1

beta cells produce

Answer 1

1. insulin
2. amylin

Question 2

alpha cells produce

Answer 2

glucagon

Question 3

delta cells produce

Answer 3

somatostatin

Question 4

stimulate insulin secretion

Answer 4

1. inc blood glucose
2. intracellular ATP
3. intracellular Ca
4. intracellular cAMP
5. parasymps via vagal
6. glucagon like peptide GLP1
7. gastric inhibitory peptide GIP

Question 5

inhibit insulin secretion

Answer 5

1. dec blood glucose
2. dec ATP
3. dec Ca
4. dec cAMP
5. sympathetics via NE
6. somatostatin

Question 6

pathway of glucose stimulated insulin release

Answer 6

1. glucose transport into beta cell thru glut 2
2. phosphorylated to glucokinase
3. metabolized to ATP
4. ATP sensitive K channels close to inc intracellular levels for depolarization
5. voltage dep Ca channels open
6. inc intracell Ca induces insulin from granules

Question 7

insulin on the liver

Answer 7

1. promotes glycogen syn/storage
2. inc protein syn
3. lipogenesis
4. inhibit glycogenolysis, ketogenesis, and gluconeogenesis

Question 8

insulin on adipose tissue

Answer 8

1. inc glucose uptake
2. inc lipogenesis/dec lipolysis

Question 9

insulin on skeletal muscle

Answer 9

1. inc glucose uptake
2. inc glycogen sy
3. inc protein syn

Question 10

stimulants of glucagon

Answer 10

1. hypoglycemia
2. hormones- CCK, cortisol, gastrin
3. sympathetics
4. vagal stim

Question 11

inhibitors of glucagon

Answer 11

1. glucose
2. somatostatin
3. insulin
4. GABA
5. GLP1

Question 12

effect of amylin

Answer 12

1. dec glucagon secretion
2. inhibit GI motility
3. regulate appetite

Question 13

effect of GLP1

Answer 13

1. promote insulin and beta cell growth
2. inhibit glucagon
3. dec GI motility
4. dec appetite
5. dec BP
6. inc HR
7. inc glycogen synthesis in muscle

degraded by DPP4