Viral Infections of GI Tract II Flashcards
(33 cards)
What genome family is the polio virus from
picornaviridae (RNA)
Poliovirus virions stable at _______
acidic pH
What are the serotypes of poliovirus
P1, P2, P3
How is poliovirus transmitted
fecal-oral
What is the incubation period for poliovirus
6 to 20 days
Where is the poliovirus currently endemic
Afghanistan
Nigeria
Pakistan
What are the clinical manifestations of poliovirus
asymptomatic
abortive poliomyelitis
nonparalytic aseptic meningitis
flaccid paralysis
Symptoms for abortive poliomyelitis
sore throat
fever, vomiting, constipation
NO paralysis
Symptoms for nonparalytic aseptic meningitis
nonspecific prodromal symptoms
stiffness is back, neck, or legs
lasts for 2 to 10 days
How can you diagnose poliovirus
can be isolated from stool of patients
What was a potential risk of the trivalent, live attenuated oral polio vaccine
VAPP
Symptoms of viral gastroenteritis
inflammation of stomach and intestines, nausea, diarrhea, vomiting
How is viral gastroenteritis spread
fecal oral
Is viral gastroenteritis enveloped
no
What are the types of viral gastroenteritis
rotavirus, norovirus, adenovirus, astrovirus
What are the major differences between viral and bacterial gastroenteritis
viral has a longer incubation period, prominent vomiting, and nonbloody stool
Signs of severe dehyrdation
rapid, weak pulse, sunken eyes, tears absent, skin tenting, lack of urination
Who does rotavirus most commonly affect
young kids
What is unique about the rotavirus
it has a segmented genome, which remains in the core particle during infection
Is rotairus a major opportunistic pathogen in HIV infections?
NOPE
When is rotavirus season?
later winter/early spring
Rotavirus produces a toxin _____ that causes _____ release
NSP4
Ca++
How do you diagnose rotavirus
EIA from stool sample
How do you treat viral gastroentritis
oral rehydration for mild
IV rehdration for severe
