VIROLOGY - Filoviridae, FLAVIVIRUSES, HEPEVIRUS, HEPADNAVIRUS

Question 1

flaviviridae’s structure

Answer 1

enveloped positive sense ssRNA

Question 2

important arthropod-borne viruses in human and veterinary medicine

Answer 2

flavivirus

Question 3

MOT for flaviviridae

Answer 3

mosquitoes and ticks

Question 4

geographical distribution of flaviviridae

Answer 4

worldwide expect polar regions

Question 5

what are the mosquito borne flaviviruses

Answer 5

• Encephalitis viruses
• St. Louis Encephalitis: Americas, Caribbean
• Japanese Encephalitis: N and SE Asia, India
• Murray Valley Encephalitis: Australia
• West Nile: Africa, Asia, Europe
• Ilheus: Central and South America
• Yellow Fever
• Dengue types 1, 2, 3 , 4

Question 6

what are the tick borne flaviviruses

Answer 6

• Russian Spring-Summer Encephalitis: Russia
  -Central European Encephalitis: Western and Central Europe

Question 7

what does it mean to be an arboviruses

Answer 7

the vectors are arthropods

Question 8

flavivirus; name is derived from the latin flavus means

Answer 8

yellow

Question 9

Zira virus infection were discovered in what country

Answer 9

brazil

Question 10

what is the first disease identified in flaviviridae

Answer 10

yellow fever

Question 11

the out break in brazil caused by zika virus led to reports of what syndrome, it was been find out as well to cause pregnant women giving birth to babies with birth defects and poor pregnancy outcomes

Answer 11

guillain barre syndrome; zika virus

Question 12

this disease caused by a flaviviridae became one of the great plagues throughout the history and is known to cause jaundice to patients

Answer 12

yellow fever

Question 13

reservoir and vector of yellow fever

Answer 13

monkey as reservoir and mosquito is the vector

Question 14

the first virus clearly associated with transmission by a mosquito

Answer 14

yellow fever - flavivirus

Question 15

incubation period of yellow fever

Answer 15

3-6 days

Question 16

mortality rate of yellow fever

Answer 16

5-50%

Question 17

vector of yellow fever

Answer 17

aedes agypti

Question 18

the post prevalent arbovirus in the world

Answer 18

dengue virus

Question 19

vector of dengue virus

Answer 19

aedes aegypti

Question 20

reservoir of dengue virus

Answer 20

human is the natural reservoir

Question 21

most important mosquito borne disease in the USA

Answer 21

st. louis encephalitis virus

Question 22

vector of st. louis encephalitis

Answer 22

culex tarsalis

Question 23

reservoir of st. louis encephalitis

Answer 23

wild birds

Question 24

diagnosis for yellow fever

Answer 24

rt pcr, serologic assays, and histology

Question 25

rx or prevention of yellow fever

Answer 25

no specific antiviral treatment supportive care vector control live attenuated vaccine 17-d vaccine

Question 26

first isolated from a febrile human in the west nile district of uganda in 1937

Answer 26

west nile virus

Question 27

are responsible for transmission from birds to humans

Answer 27

bridge mosquitoes

Question 28

principal mosquito vector pf murray valley encephalitis virus

Answer 28

Culex annulirostris

Question 29

caused by a group B arbovirus (Flavivirus) and transmitted by Culex mosquitoes

Answer 29

JAPANESE ENCEPHALITIS

Question 30

rural mosquito that breeds in rice fields -principal vector of japanese encephalitis

Answer 30

Culex tritaeniorhynchus

Question 31

Control of Japanese Encephalitis

Answer 31

1. Formalin inactivated mouse brain vaccine-Nakayama strain 2. Live attenuated vaccine—from JE strain SA 14142, 3. Vaccination of pigs

Question 32

Tick-Borne Flavivirus

Answer 32

Russian Spring-Summer encephalitis (RSSE) complex Central European Encephalitis

Question 33

MOT of hepacivirus

Answer 33

parenteral/sexual

Question 34

diagnosis for hepacivirus

Answer 34

anti-HCV EIA RT PCR quantitative bDNA

Question 35

this hepa virus is Usually undiagnosed as it is asymptomatic

Answer 35

HCV

Question 36

used to monitor antiviral therapy of HCV

Answer 36

RT PCR and quantitative bDNA