Flashcards in Viruses and Prions Deck (161)
What is the morphology of human papilloma virus?
non-enveloped DNA papovirus surrounded by an icosahedral nucleocapsid
Name two classic illnesses associated with arbovirus.
dengue fever (in SE Asia= hemorrhagic shock syndrome) and yellow fever
What is the most appropriate way of diagnosing molluscipoxvirus?
Do hepadnavirus, herpesviruses, and poxvirus have an envelope?
What are the clinical manifestations of Epstein-Barr virus? (2)
infectious mononucleosis-fever, sore throat, lymphadenopathy and splenomegaly. Chronic fatigue syndrome (putative). Burkitt's lymphoma-association not clear, but EBV may be capable of inducing malignant transformations.
What are the clinical manifestations of smallpox virus? (3)
smallpox (eradicated) 12-14 days incubation followed by sudden fever, chills, myalgia, then a rash that turns pustular and slow to heal. 35% mortality.
Name the diseases caused by HSV-1. (4)
gingivostomatitis, keratoconjunctivitis, temporal lobe encephalitis, herpes labialitis
Which hepatitis virus has a short incubation period?
hep A (3 weeks)
Name the routes of transmission for HSV-2. (2)
sexual contact, perinatal
Describe the clinical course of mumps. (4)
14-24 day incubation period followed by prodrome of fever, malaise and anorexia, then swelling of parotid glands (usually bilateral).
What is the most common association with coxsackie viruses?
most common non-bacterial CNS infection in North America
Name the diseases caused by HSV-2. (2)
herpes genitalis, neonatal herpes
Name two complications of mumps.
orchitis (danger of sterility) and meningitis (self limiting)
List four symptoms of mononucleosis.
fever, hepatosplenomegaly, pharyngitis, and lymphadenopathy (esp posterior auricular nodes)
When lab findings are useful to help diagnose cytomegalovirus? (4)
cell culture; tissue staining shows owl's eye inclusion bodies; PCR and immunfluorescent staining available
Name two virus families with circular DNA
papilomavirus and hepadnavirus
What is the morphology of hepatitis C?
rNA flavivirus, eveloped
Identify the major virulence factor associated with respiratory syncytial virus.
f glycoprotein in envelope causes cells to fuse (syncytium).
Identify relevant epidemiology and risk factors associated with rhinovirus.
epidemics in spring and fall
The common cold is caused by which virus?
What is the morphology of rotavirus?
a reovirus-double stranded RNA virus, no envelope
Name three symptoms of yellow fever.
high fever, black vomitus and jaundice
Identify relevant epidemiology and risk factors associated with hepatitis A. (2)
children; occasional epidemics from restaurants (fecally contaminated food or water)
Identify the major virulence factors associated with humanimmunodeficiency virus. (2)
gp 120 and gp 41 on its envelope
What are the clinical manifestations of hepatitis B? (3)
chronic hepatitis-10-12 week incubation followed by fever, nausea and jaundice with hepatomegaly, dark urine, malaise, lasting two weeks. 1-2 weeks after recovery, intermittent arthralgia, fatigue, jaundice, cholestasis and pruritis.
What is the morphology of hepatitis A?
rNA enterovirus, non enveloped
What lab findings are useful to help diagnose Herpes simplex (I and II)?
cell culture; ELISA or PCR testing of the lesion
What are the clinical manifestations of adenovirus? (6)
acute respiratory disease (miliary). Pneumonia (infants). Pharyngitis and or conjunctivitis (with fever). gastroenteritis. Hemorrhagic cystitis (dysuria, mild pain on urination, gross hematuria).
How is human immunodeficiency virus transmitted?
exchange of body fluids (requires high infective dose)