Viruses II

Question 1

negative strand RNA in single strand

• HA and NA same glycoprotein spike
• fusion F protein

Answer 1

paramyxoviridae

-lungs, kids, viremia

Question 2

F protein

Answer 2

fusion protein

• causes infected host cells to fuse together
• in multinucleated giant cells

-paramyxoviridae

Question 3

parainfluenza virus

Answer 3

paramyxoviridae

-rhinitis, pharyngitis, bronchitis

Question 4

croup

Answer 4

parainfluenza infection of larynx
-in children

• airway narrowing
• stridor

Question 5

respiratory syncytial virus

Answer 5

paramyxoviridae

• respiratory infection
• F protein - causes formation of multinucleated giant cells

Question 6

number one cause of pneumoniae in children

-especially infants less than 6 months of age

Answer 6

respiratory syncytial virus

Question 7

metapneumovirus

Answer 7

paramyxoviridae

• second most common cause of lower resp infections in young children
• around 1 year old

-bronchiolitis, croup, pneumonia

Question 8

mumps virus

Answer 8

paramyxoviridae

• infection of parotid gland
• orchitis in testes

Question 9

parotid infection and testes orchitis

Answer 9

mumps virus

Question 10

MMR vaccine

Answer 10

measles
mumps
rubella

Question 11

measles virus

Answer 11

paramyxoviridae

• prodrome syndrome
• kopliks spots
• rash

Question 12

prodrome of measles

Answer 12

conjunctivitis
eyelid swelling
photophobia
high fever
hacking cough
rhinitis
malaise

Question 13

kopliks spots

Answer 13

in measles

• day or two before rash
• small red-based lesions with blue-white centers in mouth

Question 14

small red-based lesions with blue-white centers in mouth

Answer 14

kopliks spots

-measles

Question 15

measles rash

Answer 15

red, flat bumpy

• spreads from forehead to face to neck to torso
• disappears as it develops

Question 16

subacute sclerosing panencephalitis

Answer 16

slow form of encephalitis
-caused by measles virus

many years after infection- child or adolescent has slow CNS deterioration with incoordination

Question 17

hepatitis

Answer 17

RNA viruses

-infects hepatocytes

Question 18

fatigue, low grade fever, cough, aches, runny nose, pharyngitis, jaundice, elevated liver enzymes

Answer 18

acute viral hepatitis

Question 19

chronic viral hepatitis

Answer 19

patient often asymptomatic with enlarged tender liver and slight elevated liver enzymes

Question 20

hepatocytes produce

Answer 20

AST and ALT

Question 21

bile canaliculi produce

Answer 21

alkaline phosphatase and GGT

Question 22

viral hepatitis enzymes

Answer 22

very high AST and ALT

slightly elevated alkaline phosphatase and GGT

Question 23

bile stone

Answer 23

very high alkaline phosphatase and GGT

-bilirubin in blood

Question 24

naked icosahedral with positive single strand RNA

Answer 24

hepatitis A virus

• family picornaviridae
• fecal-oral transmission

Question 25

hepatitis A virus

Answer 25

acute hepatitis | -in youngh children

Question 26

anti-HAV IgM in serum

Answer 26

active infection of Hep A

Question 27

anti-HAV IgG in serum

Answer 27

old infection of Hep A

Question 28

dane particle

Answer 28

intact hepatitis B virus | -large

Question 29

double stranded circular DNA with enveloped icosahedral capsule

Answer 29

hepatitis B - also has hepatitis B surface antigen - HBsAg, HBcAg, and BHeAg

Question 30

HBeAg

Answer 30

marker for active disease of hepatitis B

Question 31

anti-HBsAg

Answer 31

patient immune against hepatitis B

Question 32

parenteral

Answer 32

blood to blood transmission

Question 33

fulminant hepatitis

Answer 33

severe acute hepatitis with rapid destruction of liver | -hepatitis B

Question 34

low grade smoldering hepatitis

Answer 34

chronic persistent hepatitis

Question 35

chronic active hepatitis

Answer 35

acute lasting longer than 6-12 months

Question 36

hepatitis co-infection

Answer 36

hepatitis B and hepatitis delta

Question 37

primary hepatocellular carcinoma

Answer 37

complication of hepatitis B 200x increased rixk

Question 38

cirrhosis

Answer 38

with hepatitis B

Question 39

HBsAg

Answer 39

indicates disease state of hepatitis B

Question 40

anti-HBsAg

Answer 40

indicates immunity, cure, and no active disease

Question 41

IgM anti-HBcAg

Answer 41

new infection

Question 42

IgG anti-HBcAg

Answer 42

old infection

Question 43

HBeAg

Answer 43

high infectivity of hepatitis B

Question 44

anti-HBeAg

Answer 44

low infectivity of hepatitis B

Question 45

relapse of hepatitis B

Answer 45

always possible